{"id":1533,"date":"2026-09-17T17:36:15","date_gmt":"2026-09-17T09:36:15","guid":{"rendered":"https:\/\/shandong.nugene.com.cn\/?p=1533"},"modified":"2026-09-17T17:36:17","modified_gmt":"2026-09-17T09:36:17","slug":"%e6%96%87%e7%8c%ae%e8%a7%a3%e8%af%bb%ef%bd%9cmk7%e7%94%b2%e8%90%98%e9%86%8c7-%e5%87%8f%e8%bd%bb%e8%84%82%e8%b4%a8%e4%bd%93%e5%8c%96%e7%96%97%e8%8d%af%e6%89%8b%e8%b6%b3%e7%bb%bc%e5%90%88%e5%be%81","status":"publish","type":"post","link":"https:\/\/shandong.nugene.com.cn\/index.php\/%e6%96%87%e7%8c%ae%e8%a7%a3%e8%af%bb%ef%bd%9cmk7%e7%94%b2%e8%90%98%e9%86%8c7-%e5%87%8f%e8%bd%bb%e8%84%82%e8%b4%a8%e4%bd%93%e5%8c%96%e7%96%97%e8%8d%af%e6%89%8b%e8%b6%b3%e7%bb%bc%e5%90%88%e5%be%81\/","title":{"rendered":"\u6587\u732e\u89e3\u8bfb\uff5cMK7\u7532\u8418\u918c7 \u51cf\u8f7b\u8102\u8d28\u4f53\u5316\u7597\u836f\u624b\u8db3\u7efc\u5408\u5f81"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-7-1024x576.jpeg\" alt=\"\" class=\"wp-image-1534\" srcset=\"https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-7-1024x576.jpeg 1024w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-7-300x169.jpeg 300w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-7-1536x864.jpeg 1536w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-7-768x432.jpeg 768w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-7.jpeg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5236\u5242\u7814\u7a76\u89e3\u8bfb<\/strong><\/p>\n\n\n\n<h1 class=\"wp-block-heading\">\u6587\u732e\u89e3\u8bfb\uff5cMK7\u7532\u8418\u918c7 \u51cf\u8f7b\u8102\u8d28\u4f53\u5316\u7597\u836f\u624b\u8db3\u7efc\u5408\u5f81<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Journal of Drug Delivery Science and Technology 2026\uff5c\u6c88\u9633\u836f\u79d1\u5927\u5b66\u5236\u5242\u7814\u7a76<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">MK7 \u624b\u8db3\u7efc\u5408\u5f81 \u8102\u8d28\u4f53 \u7c73\u6258\u84bd\u918c \u51cf\u6bd2<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\">1:1MK7\/\u836f\u8d28\u91cf\u6bd4<\/td><td class=\"has-text-align-center\" data-align=\"center\">HFS\u624b\u8db3\u7efc\u5408\u5f81<\/td><td class=\"has-text-align-center\" data-align=\"center\">MK7\u4fdd\u62a4\u6700\u4f18<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5bfc\u8bfb<\/strong>\u6c88\u9633\u836f\u79d1\u5927\u5b66\u56e2\u961f\u5728 Journal of Drug Delivery Science and Technology \u53d1\u8868\u7814\u7a76\uff1a\u5c06 MK7 \u4e0e\u7c73\u6258\u84bd\u918c\u5171\u8f7d\u5165 PEG \u5316\u8102\u8d28\u4f53\uff0c\u53ef\u5242\u91cf\u4f9d\u8d56\u6027\u51cf\u8f7b\u5927\u9f20\u624b\u8db3\u7efc\u5408\u5f81\uff0c\u540c\u65f6\u4fdd\u7559\u6297\u80bf\u7624\u836f\u6548\uff1b\u6a2a\u5411\u5bf9\u6bd4\u4e2d MK7 \u4f18\u4e8e MK4 \u4e0e VK\u2081\u3002\u8fd9\u662f\u5236\u5242\u6539\u9020\u601d\u8def\uff0c\u4e0d\u7b49\u4e8e\u53e3\u670d MK7 \u53ef\u9632\u6cbb\u4e34\u5e8a\u5316\u7597\u624b\u8db3\u7efc\u5408\u5f81\u3002<img decoding=\"async\" src=\"blob:https:\/\/shandong.nugene.com.cn\/66e966f0-aca9-4260-8385-66431316eb35\" alt=\"\u539f\u6587\u6587\u732e\u6807\u9898\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u6587\u6587\u732e\uff5cJournal of Drug Delivery Science and Technology \u00b7 MK7 \u5171\u8f7d\u51cf\u6bd2\u6807\u9898\u9875<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e00\u3001\u7814\u7a76\u80cc\u666f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">PEG\u5316\u957f\u5faa\u73af\u8102\u8d28\u4f53\u662f\u80bf\u7624\u5316\u7597\u91cd\u8981\u7eb3\u7c73\u5236\u5242\uff0c\u53ef\u5ef6\u957f\u836f\u7269\u5faa\u73af\u3001\u63d0\u5347\u80bf\u7624\u9776\u5411\u3002\u4f46PEG\u4fee\u9970\u4f1a\u5e26\u6765\u4e00\u7c7b\u5171\u6027\u526f\u4f5c\u7528\u2014\u2014\u624b\u8db3\u7efc\u5408\u5f81HFS\uff1a\u624b\u638c\u8db3\u5e95\u7ea2\u6591\u3001\u80bf\u80c0\u3001\u8131\u76ae\u3001\u6e83\u75a1\uff1b\u4e25\u91cd\u65f6\u5fc5\u987b\u505c\u836f\u3001\u51cf\u91cf\uff0c\u76f4\u63a5\u5f71\u54cd\u80bf\u7624\u6cbb\u7597\u3002\u76ee\u524d\u4e34\u5e8a\u4e0a\u7f3a\u5c11\u5b89\u5168\u6709\u6548\u7684\u9632\u6cbb\u624b\u6bb5\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7c73\u6258\u84bd\u918c\u8102\u8d28\u4f53\u662f\u84bd\u73af\u7c7b\u5316\u7597\u836f\uff0c\u540c\u6837\u91c7\u7528PEG\u957f\u5faa\u73af\u7ed3\u6784\u3002\u6b64\u524d\u6ca1\u6709\u7cfb\u7edf\u52a8\u7269\u6a21\u578b\u8bc1\u5b9e\u5b83\u662f\u5426\u4f1a\u8bf1\u53d1\u624b\u8db3\u7efc\u5408\u5f81\u3002MK7\uff08\u7ef4\u751f\u7d20K\u20827\uff09\u62e5\u6709\u7a81\u51fa\u7684NF\u03baB\u6297\u708e\u6d3b\u6027\uff0c\u8102\u6eb6\u6027\u9ad8\uff0c\u53ef\u5d4c\u5165\u8102\u8d28\u4f53\u78f7\u8102\u53cc\u5206\u5b50\u5c42\u3002\u672c\u8bfe\u9898\u6784\u5efaMK7\u4e0e\u7c73\u6258\u84bd\u918c\u5171\u8f7d\u8102\u8d28\u4f53\uff0c\u9a8c\u8bc1\u51cf\u6bd2\u662f\u5426\u53ef\u884c\uff0c\u540c\u65f6\u6a2a\u5411\u5bf9\u6bd4MK4\u3001VK\u2081\u7ef4\u751f\u7d20K\u5bb6\u65cf\u4e0d\u540c\u6210\u5458\u7684\u4fdd\u62a4\u6548\u679c\u3002<img decoding=\"async\" src=\"blob:https:\/\/shandong.nugene.com.cn\/a6b5d540-466a-4d02-817c-fc5587d706a8\" alt=\"\u63d2\u56fe1\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u56fe1\uff5c\u624b\u8db3\u7efc\u5408\u5f81\u7167\u62a4\u610f\u8c61\uff1aPEG \u8102\u8d28\u4f53\u5316\u7597\u76f8\u5173\u76ae\u80a4\u6bd2\u6027\u7684\u4eba\u6587\u573a\u666f<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6838\u5fc3\u8bd5\u9a8c\u8981\u70b9<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5efa\u7acb\u5927\u9f20\u7c73\u6258\u84bd\u918c\u8102\u8d28\u4f53\u624b\u8db3\u7efc\u5408\u5f81\u52a8\u7269\u6a21\u578b\uff0c\u53ef\u590d\u523b\u4e34\u5e8a\u7ea2\u6591\u3001\u80bf\u80c0\u3001\u6e83\u75a1\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5236\u5907MK7\/\u7c73\u6258\u84bd\u918c\u5171\u8f7d\u8102\u8d28\u4f53\uff0c\u8003\u5bdf\u624b\u8db3\u76ae\u80a4\u635f\u4f24\u3001\u5168\u8eab\u810f\u5668\u6bd2\u6027\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4T1\u4e73\u817a\u764c\u8377\u7624\u5c0f\u9f20\u8bc4\u4ef7\uff1a\u91cd\u70b9\u770b\u51cf\u6bd2\u540c\u65f6\u662f\u5426\u4fdd\u7559\u6297\u80bf\u7624\u836f\u6548\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6a2a\u5411\u5bf9\u6bd4MK7\u3001MK4\u3001VK\u2081\u4e09\u79cd\u7ef4\u751f\u7d20K\u8102\u8d28\u4f53\u7684\u4fdd\u62a4\u80fd\u529b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e8c\u3001\u5173\u952e\u8bd5\u9a8c\u7ed3\u679c<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MK7\u5242\u91cf\u4f9d\u8d56\u6027\u9884\u9632\u624b\u8db3\u7efc\u5408\u5f81\u3001\u964d\u4f4e\u5168\u8eab\u6bd2\u6027<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0d\u6dfb\u52a0MK7\u7684\u7c73\u6258\u84bd\u918c\u8102\u8d28\u4f53\u7ec4\u51fa\u73b0\u4e25\u91cd3\u7ea7\u624b\u8db3\u6e83\u75a1\uff1b\u968f\u7740MK7\u6295\u6599\u6bd4\u4f8b\u5347\u9ad8\uff0c\u722a\u5b50\u635f\u4f24\u9010\u6b65\u51cf\u8f7b\uff1bMK7\u4e0e\u7c73\u6258\u84bd\u918c\u8d28\u91cf\u6bd41:1\u7ec4\uff0c\u5927\u9f20\u722a\u5b50\u51e0\u4e4e\u65e0\u660e\u663e\u624b\u8db3\u7efc\u5408\u5f81\u75c7\u72b6\u3002\u540c\u65f6\u8840\u6e05\u4fc3\u708e\u56e0\u5b50IL1\u03b2\u3001TNF\u03b1\u3001IL6\u663e\u8457\u4e0b\u964d\uff0c\u5fc3\u808c\u3001\u809d\u810f\u3001\u813e\u810f\u810f\u5668\u75c5\u7406\u635f\u4f24\u5f97\u5230\u660e\u663e\u7f13\u89e3\u3002MK7\u4e0d\u4f1a\u6539\u53d8\u7c73\u6258\u84bd\u918c\u5728\u4f53\u5185\u836f\u4ee3\u5faa\u73af\u884c\u4e3a\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u6587\u56fe\u8868<img decoding=\"async\" src=\"blob:https:\/\/shandong.nugene.com.cn\/2d730b76-c426-42e6-9691-74e022762590\" alt=\"\u539f\u6587\u56fe\u88681\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u6587 Fig. 3\uff5cMK7 \u5171\u8f7d\u5242\u91cf\u8d8a\u9ad8\uff0c\u5927\u9f20\u624b\u8db3\u7efc\u5408\u5f81\u8d8a\u8f7b\uff1b1:1 \u7ec4\u722a\u5b50\u51e0\u4e4e\u65e0\u660e\u663e\u6e83\u75a1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297\u80bf\u7624\u836f\u6548\uff1a\u51cf\u6bd2\u4e0d\u51cf\u7597\u6548<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u57284T1\u4e73\u817a\u764c\u5c0f\u9f20\u6a21\u578b\uff0cMK7\/MIT\u5171\u8f7d\u5236\u5242\u80bf\u7624\u6291\u5236\u6548\u679c\u548c\u5355\u7eaf\u7c73\u6258\u84bd\u918c\u8102\u8d28\u4f53\u76f8\u5f53\uff0c\u6297\u80bf\u7624\u6d3b\u6027\u6ca1\u6709\u88ab\u524a\u5f31\u3002\u5e76\u4e14\u5c0f\u9f20\u4f53\u91cd\u6062\u590d\u66f4\u597d\uff0c\u5728LPS\u5185\u6bd2\u7d20\u611f\u67d3\u5e94\u6fc0\u653b\u51fb\u4e0b\uff0c\u5c0f\u9f20\u751f\u5b58\u7387\u663e\u8457\u4f18\u4e8e\u5355\u7eaf\u5316\u7597\u7ec4\uff0c\u4ee3\u8868\u52a8\u7269\u6574\u4f53\u8010\u53d7\u3001\u6297\u5e94\u6fc0\u80fd\u529b\u63d0\u5347\u3002<img decoding=\"async\" src=\"blob:https:\/\/shandong.nugene.com.cn\/96f212cf-414c-427d-a6ab-ea2c82c44cda\" alt=\"\u63d2\u56fe2\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u56fe2\uff5cMK7 \u5171\u8f7d\u8102\u8d28\u4f53\u903b\u8f91\u793a\u610f\uff1a\u5d4c\u5165\u78f7\u8102\u53cc\u5206\u5b50\u5c42\u3001\u6297\u708e\u51cf\u6bd2\uff08\u975e\u7ebf\u6761\u7ed3\u6784\u56fe\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e09\u79cd\u7ef4\u751f\u7d20K\u6a2a\u5411\u5bf9\u6bd4\uff1aMK7\u4fdd\u62a4\u6548\u679c\u6700\u4f18<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">MK7\u3001MK4\u3001VK\u2081\u4e09\u79cd\u8102\u8d28\u4f53\u5747\u80fd\u7f13\u89e3\u624b\u8db3\u7efc\u5408\u5f81\u3002\u5176\u4e2dVK\u2081\u6548\u679c\u6700\u5f31\uff0cMK4\u4e2d\u7b49\uff1bMK7\u56e0\u4e3a\u957f\u5f02\u620a\u4e8c\u70ef\u4fa7\u94fe\uff0c\u8102\u6eb6\u6027\u66f4\u9ad8\uff0c\u4f53\u5185\u6ede\u7559\u65f6\u95f4\u66f4\u957f\uff0c\u6297\u708e\u4fdd\u62a4\u6548\u679c\u6700\u4e3a\u7a81\u51fa\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u6587\u56fe\u8868<img decoding=\"async\" src=\"blob:https:\/\/shandong.nugene.com.cn\/1249ea46-d910-4eee-a5f2-c901f4fa20a6\" alt=\"\u539f\u6587\u56fe\u88682\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u6587 Fig. 7\uff5cMK7\u3001MK4\u3001VK\u2081 \u6a2a\u5411\u5bf9\u6bd4\uff1a\u4e09\u79cd\u7ef4\u751f\u7d20 K \u8102\u8d28\u4f53\u5747\u80fd\u7f13\u89e3 HFS\uff0cMK7 \u4fdd\u62a4\u6700\u7a81\u51fa<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u63d0\u793a\u4e0e\u5c40\u9650<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u673a\u5236\uff1aMK7\u4e0d\u6539\u53d8\u8102\u8d28\u4f53\u4f53\u5185\u5206\u5e03\uff0c\u4e3b\u8981\u901a\u8fc7\u6291\u5236NF\u03baB\u901a\u8def\u3001\u4e0b\u8c03\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff0c\u963b\u65ad\u201c\u836f\u7269\u84c4\u79ef\u708e\u75c7\u7206\u53d1\u7ec4\u7ec7\u635f\u4f24\u201d\u94fe\u6761\uff1b<\/p>\n\n\n\n<p 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