{"id":1541,"date":"2026-09-22T14:52:08","date_gmt":"2026-09-22T06:52:08","guid":{"rendered":"https:\/\/shandong.nugene.com.cn\/?p=1541"},"modified":"2026-09-22T14:52:11","modified_gmt":"2026-09-22T06:52:11","slug":"%e5%ad%95%e6%9c%9f%ef%bc%9a%e5%8f%b6%e9%85%b8%e4%b8%8e5-mthf%e6%b4%bb%e6%80%a7%e5%8f%b6%e9%85%b8%e7%9a%84%e5%a4%b4%e5%af%b9%e5%a4%b4%e5%af%b9%e7%85%a7","status":"publish","type":"post","link":"https:\/\/shandong.nugene.com.cn\/index.php\/%e5%ad%95%e6%9c%9f%ef%bc%9a%e5%8f%b6%e9%85%b8%e4%b8%8e5-mthf%e6%b4%bb%e6%80%a7%e5%8f%b6%e9%85%b8%e7%9a%84%e5%a4%b4%e5%af%b9%e5%a4%b4%e5%af%b9%e7%85%a7\/","title":{"rendered":"\u5b55\u671f\uff1a\u53f6\u9178\u4e0e5-MTHF\u6d3b\u6027\u53f6\u9178\u7684\u5934\u5bf9\u5934\u5bf9\u7167"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-10-1024x576.jpeg\" alt=\"\" class=\"wp-image-1543\" srcset=\"https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-10-1024x576.jpeg 1024w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-10-300x169.jpeg 300w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-10-768x432.jpeg 768w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-10-1536x864.jpeg 1536w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-10.jpeg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h1 class=\"wp-block-heading\">\u5b55\u671f\uff1a\u53f6\u9178\u4e0e5-MTHF\u6d3b\u6027\u53f6\u9178\u7684\u5934\u5bf9\u5934\u5bf9\u7167<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Clinical Nutrition ESPEN 2026\uff5c\u5370\u5ea6\u5c3c\u897f\u4e9a\u5b55\u5987\u53cc\u76f2\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53f6\u9178 5-MTHF \u5b55\u671f RCT \u540c\u578b\u534a\u80f1\u6c28\u9178<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\">110\u4f8b\u5165\u7ec4\u5b55\u5987<\/td><td class=\"has-text-align-center\" data-align=\"center\">12\u5468\u7b49\u6469\u5c14\u5242\u91cf\u5e72\u9884<\/td><td class=\"has-text-align-center\" data-align=\"center\">96\u4f8b\u5b8c\u6210\u8bd5\u9a8c<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5bfc\u8bfb<\/strong>\u8bfb\u8fd9\u7bc7\u5148\u8bb0\u4f4f\u8fb9\u754c\uff1a\u5b83\u6bd4\u8f83\u7684\u662f\u5b55\u5987\u8865\u5145\u4e4b\u540e\u7684\u8840\u6db2\u6307\u6807\uff0c\u4e0d\u662f\u4e24\u79cd\u53f6\u9178\u8c01\u66f4\u80fd\u9884\u9632\u795e\u7ecf\u7ba1\u7f3a\u9677\u3002\u957f\u671f\u50a8\u5907\u3001\u8840\u6d46\u6d3b\u6027\u53f6\u9178\u3001\u672a\u4ee3\u8c22\u53f6\u9178\uff0c\u4e09\u9879\u7ed3\u8bba\u5e76\u4e0d\u7ad9\u5728\u540c\u4e00\u8fb9\u3002\u540e\u9762\u7684\u6570\u5b57\uff0c\u90fd\u8981\u653e\u5728\u8fd9\u4e2a\u8fb9\u754c\u91cc\u770b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"401\" src=\"https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-11-1024x401.jpeg\" alt=\"\" class=\"wp-image-1542\" srcset=\"https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-11-1024x401.jpeg 1024w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-11-766x300.jpeg 766w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-11-300x117.jpeg 300w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/09\/image-11.jpeg 1400w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u6587\u6807\u9898\u9875\uff5cClinical Nutrition ESPEN \u00b7 Comparative bioavailability of 5-methyltetrahydrofolate and folic acid in pregnant women<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e00\u3001\u4e3a\u4ec0\u4e48\u8981\u505a\u8fd9\u6b21\u5934\u5bf9\u5934\u6bd4\u8f83<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u666e\u901a\u5408\u6210\u53f6\u9178\uff08FA\uff09\u9700\u8981\u4eba\u4f53\u4f9d\u9760 MTHFR \u9176\u4ee3\u8c22\u8f6c\u5316\uff0c\u624d\u4f1a\u751f\u6210\u6d3b\u6027\u5f62\u5f0f 5-\u7532\u57fa\u56db\u6c22\u53f6\u9178\uff085-MTHF\uff09\u3002\u4e9a\u6d32\u4eba\u7fa4 MTHFR \u57fa\u56e0\u7a81\u53d8\u6bd4\u4f8b\u8f83\u9ad8\uff0c\u90e8\u5206\u4eba\u9176\u6d3b\u6027\u4e0d\u8db3\u3002\u76f4\u63a5\u8865\u5145 5-MTHF\uff0c\u7406\u8bba\u4e0a\u53ef\u4ee5\u7ed5\u5f00\u8fd9\u4e00\u4ee3\u8c22\u6b65\u9aa4\u3002\u4f46\u9488\u5bf9\u5b55\u5987\u3001\u800c\u4e14\u662f\u5934\u5bf9\u5934\u7684\u5927\u6837\u672c\u968f\u673a\u5bf9\u7167\u8bc1\u636e\uff0c\u6b64\u524d\u5e76\u4e0d\u5145\u5206\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u91c7\u7528\u7b49\u6469\u5c14\u5242\u91cf\uff0c\u6bd4\u8f83\u666e\u901a\u53f6\u9178\u4e0e\u6c28\u57fa\u8461\u8404\u7cd6\u76d0 5-MTHF\uff0c\u5e72\u9884 12 \u5468\uff0c\u89c2\u5bdf\u5b55\u5987\u53f6\u9178\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\u7684\u53d8\u5316\u3002<img decoding=\"async\" src=\"blob:https:\/\/shandong.nugene.com.cn\/b279f1ea-e3cf-4d1e-9a9d-8828b8d19ae8\" alt=\"\u539f\u6587 Fig. 1\uff5c\u53f6\u9178\u5faa\u73af\u4e0e\u7532\u786b\u6c28\u9178\u5faa\u73af\uff1a\u666e\u901a\u53f6\u9178\u9700\u7ecf MTHFR \u7b49\u6b65\u9aa4\u8f6c\u5316\u4e3a 5-MTHF\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u6587 Fig. 1\uff5c\u53f6\u9178\u5faa\u73af\u4e0e\u7532\u786b\u6c28\u9178\u5faa\u73af\uff1a\u666e\u901a\u53f6\u9178\u9700\u7ecf MTHFR \u7b49\u6b65\u9aa4\u8f6c\u5316\u4e3a 5-MTHF<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u8bd5\u9a8c\u8bbe\u8ba1\u8981\u70b9<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bf9\u8c61\uff1a\u5b55 9\u201314 \u5468\u5b55\u5987\u3002\u4e00\u5171\u5165\u7ec4 110 \u4f8b\uff0c96 \u4f8b\u5b8c\u6210\u8bd5\u9a8c\u3002\u53cc\u76f2\u968f\u673a\u5bf9\u7167\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5242\u91cf\u5bf9\u7b49\uff1a\u53f6\u9178 600 \u03bcg\/\u5929\uff0c\u5bf9\u6bd4\u6c28\u57fa\u8461\u8404\u7cd6\u76d0 5-MTHF 1100 \u03bcg\/\u5929\uff0c\u6469\u5c14\u5f53\u91cf\u51e0\u4e4e\u5b8c\u5168\u4e00\u81f4\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u89c2\u5bdf\u6307\u6807\uff1a\u7ea2\u7ec6\u80de\u53f6\u9178\uff08\u957f\u671f\u53f6\u9178\u50a8\u5907\u7684\u91d1\u6807\u51c6\uff09\u3001\u8840\u6d46\u6d3b\u6027 5-MTHF\u3001\u540c\u578b\u534a\u80f1\u6c28\u9178\u3001\u672a\u4ee3\u8c22\u53f6\u9178 UMFA\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5206\u5c42\uff1a\u6309 BMI \u5206\u4e3a\u6b63\u5e38\u4f53\u91cd\u4e0e\u8d85\u91cd\u4e9a\u7ec4\u3002<img decoding=\"async\" src=\"blob:https:\/\/shandong.nugene.com.cn\/dc7a5b8a-47b7-409e-97b8-ff85b2de8408\" alt=\"\u539f\u6587 Fig. 2\uff5cCONSORT \u6d41\u7a0b\u56fe\uff1a\u5165\u7ec4 110 \u4f8b\uff0c\u5b8c\u6210\u5e76\u7eb3\u5165\u5206\u6790 96 \u4f8b\uff08\u4e24\u7ec4\u5404 48\uff09\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u6587 Fig. 2\uff5cCONSORT \u6d41\u7a0b\u56fe\uff1a\u5165\u7ec4 110 \u4f8b\uff0c\u5b8c\u6210\u5e76\u7eb3\u5165\u5206\u6790 96 \u4f8b\uff08\u4e24\u7ec4\u5404 48\uff09<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e8c\u3001\u6838\u5fc3\u8bd5\u9a8c\u7ed3\u679c<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">1\uff5c\u957f\u671f\u53f6\u9178\u50a8\u5907\u3001\u964d\u540c\u578b\u534a\u80f1\u6c28\u9178\uff1a\u4e24\u7ec4\u6548\u679c\u76f8\u5f53<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5e72\u9884 12 \u5468\u540e\uff0c\u65e0\u8bba\u662f\u7ea2\u7ec6\u80de\u53f6\u9178\uff0c\u8fd8\u662f\u8840\u6d46\u540c\u578b\u534a\u80f1\u6c28\u9178\u7684\u4e0b\u964d\u5e45\u5ea6\uff0c\u53f6\u9178\u7ec4\u548c 5-MTHF \u7ec4\u4e4b\u95f4\u90fd\u6ca1\u6709\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002\u4e24\u79cd\u8865\u5145\u5242\u90fd\u53ef\u4ee5\u6709\u6548\u6539\u5584\u5b55\u5987\u7684\u53f6\u9178\u8425\u517b\u72b6\u6001\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2\uff5c\u8840\u6d46\u6d3b\u6027\u53f6\u9178\uff1a5-MTHF \u6709\u4f18\u52bf\u8d8b\u52bf<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">5-MTHF \u7ec4\u8840\u6d46\u6d3b\u6027 5-MTHF \u5347\u9ad8\u5e45\u5ea6\u66f4\u9ad8\uff0c\u5904\u4e8e\u8fb9\u7f18\u663e\u8457\uff08P = 0.055\uff09\u3002\u8fd9\u4e00\u8d8b\u52bf\u5728\u6b63\u5e38\u4f53\u91cd\u5b55\u5987\u8eab\u4e0a\u66f4\u660e\u663e\uff1b\u8d85\u91cd\u5b55\u5987\u4e2d\uff0c\u4e24\u7ec4\u5dee\u522b\u4e0d\u663e\u8457\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3\uff5c\u672a\u4ee3\u8c22\u53f6\u9178 UMFA\uff1a\u53f6\u9178\u7ec4\u84c4\u79ef\u66f4\u9ad8\uff0c\u4f46\u672a\u8fbe\u7edf\u8ba1\u5b66\u663e\u8457<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8865\u5145\u666e\u901a\u53f6\u9178\u4f1a\u4ea7\u751f\u672a\u4ee3\u8c22\u53f6\u9178 UMFA\u3002\u672c\u8bd5\u9a8c\u4e2d\uff0c\u53f6\u9178\u7ec4\u5347\u9ad8\u7684\u4e2d\u4f4d\u6570\u5927\u7ea6\u662f 5-MTHF \u7ec4\u7684\u4e24\u500d\uff0c\u4f46\u53d7\u6837\u672c\u6240\u9650\u6ca1\u6709\u8fbe\u5230\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002\u5c24\u5176\u5728\u8d85\u91cd\u53d7\u8bd5\u8005\u8eab\u4e0a\uff0c\u4e8c\u8005\u5dee\u8ddd\u8868\u73b0\u66f4\u7a81\u51fa\u3002<img decoding=\"async\" src=\"blob:https:\/\/shandong.nugene.com.cn\/c910a153-df2e-4f80-828b-1e22b39a6383\" alt=\"\u539f\u6587 Table 2\uff5c12 \u5468\u5e72\u9884\u524d\u540e\u53f6\u9178\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\uff1a\u8840\u6d46 5-MTHF \u7ec4\u95f4\u53d8\u5316\u66f4\u7a81\u51fa\uff08\u6821\u6b63\u540e P=0.055\uff09\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539f\u6587 Table 2\uff5c12 \u5468\u5e72\u9884\u524d\u540e\u53f6\u9178\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\uff1a\u8840\u6d46 5-MTHF \u7ec4\u95f4\u53d8\u5316\u66f4\u7a81\u51fa\uff08\u6821\u6b63\u540e P=0.055\uff09<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u63d0\u793a\u4e0e\u5c40\u9650<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u53ea\u68c0\u6d4b\u751f\u7269\u6807\u5fd7\u7269\u3002\u5165\u7ec4\u65f6\u5df2\u7ecf\u662f\u5b55 9\u201314 \u5468\uff0c\u9519\u8fc7\u4e86\u795e\u7ecf\u7ba1\u7f3a\u9677\u53d1\u751f\u7684\u5173\u952e\u7a97\u53e3\uff0c\u4e0d\u80fd\u6bd4\u8f83\u4e24\u79cd\u5236\u5242\u9884\u9632\u80ce\u513f\u795e\u7ecf\u7ba1\u7f3a\u9677\u7684\u5b9e\u9645\u4e34\u5e8a\u7ed3\u5c40\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6ca1\u6709\u505a MTHFR \u57fa\u56e0\u68c0\u6d4b\u3002\u4e9a\u6d32\u7a81\u53d8\u4eba\u7fa4\u5360\u6bd4\u9ad8\uff0c\u7406\u8bba\u4e0a\u7a81\u53d8\u4eba\u7fa4\u4f1a\u66f4\u53d7\u76ca\u4e8e 5-MTHF\uff0c\u4f46\u672c\u8bd5\u9a8c\u6ca1\u6709\u76f4\u63a5\u9a8c\u8bc1\u57fa\u56e0\u578b\u5dee\u5f02\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b63\u5e38\u4f53\u91cd\u5b55\u5987\u66f4\u80fd\u4f53\u73b0 5-MTHF \u5728\u8840\u6d46\u6d3b\u6027\u53f6\u9178\u4e0a\u7684\u4f18\u52bf\uff1b\u8d85\u91cd\u5b55\u5987\u4e24\u79cd\u8865\u5145\u5242\u7684\u5e94\u7b54\u5dee\u5f02\u4e0d\u5927\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">UMFA 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