\u5421\u54af\u55b9\u5549\u918c<\/a>; \u00a0\u5b89\u5168\u6027; \u00a0\u751f\u7269\u5b66\u529f\u80fd; \u00a0\u4ea7\u54c1\u5e94\u7528<\/p>\n\n\n\nResearch progress on functional characteristics and products of pyrroloquinoline quinone<\/p>\n\n\n\n
LI Zhong-Zhu1,2, YANG Yang1,2*<\/p>\n\n\n\n
ABSTRACT: Pyrroloquinoline quinone, as a coenzyme of oxidoreductase, is widely present in various organisms and tissues. It has unique physicochemical properties and plays an important role in various physiological functions of living organisms. Currently, pyrroloquinoline quinone\u2019s safety has been supported by a large amount of evidence, so many countries have approved its application in food and beverages. A large number of animal experiments and clinical studies have shown that pyrroloquinoline quinone can improve brain cognitive function, enhance motor recovery, repair liver injury, improve osteoporosis, and other functions. This article elaborated on the safety and regulatory status, biological functions, and application in food of pyrroloquinoline quinone, in order to provide a reference for the functional research, development, and application of pyrroloquinoline quinone products.<\/p>\n\n\n\n
KEY WORDS: pyrroloquinoline quinone; safety; biological function; product application<\/p>\n\n\n\n
0 \u5f15\u8a00<\/p>\n\n\n\n
\u5421\u54af\u55b9\u5549\u918c(pyrroloquinoline quinone, PQQ)\u5206\u5b50\u5f0f\u4e3aC14H6N2O8, \u5b66\u540d\u79f0 4,5-\u4e8c\u6c22-4,5-\u4e8c\u6c27\u4ee3-1H-\u5421\u54af\u5e76[2,3-f]\u55b9\u5549-2,7,9-\u4e09\u7fa7\u9178, \u662f\u4e00\u79cd 20 \u4e16\u7eaa 70 \u5e74\u4ee3\u672b\u53d1\u73b0\u7684\u6c34\u6eb6\u6027\u7c7b\u7ef4\u751f\u7d20, \u4f5c\u4e3a\u6c27\u5316\u8fd8\u539f\u9176\u8f85\u57fa, \u53c2\u4e0e\u547c\u5438\u94fe\u7535\u5b50\u4f20\u9012, \u662f\u7ee7\u9ec4\u7d20\u6838\u82f7\u9178\u548c\u70df\u9170\u80fa\u6838\u82f7\u9178\u4e4b\u540e\u53d1\u73b0\u7684\u7b2c 3 \u79cd\u8f85\u9176[1\u20122]\u3002PQQ \u5728\u690d\u7269\u548c\u52a8\u7269\u98df\u7269\u4e2d\u5e7f\u6cdb\u5b58\u5728, \u800c\u4eba\u4f53\u9664\u4e86\u80a0\u9053\u83cc\u7fa4\u53d1\u9175\u4ea7\u751f\u5c11\u91cf PQQ \u5916, \u4e3b\u8981\u4f9d\u9760\u81b3\u98df\u6444\u53d6[3\u20124]\u3002\u8fd1\u5e74\u6765\u7684\u5927\u91cf\u7814\u7a76\u663e\u793a PQQ \u662f\u5f71\u54cd\u7ebf\u7c92\u4f53\u751f\u7269\u53d1\u751f\u548c\u80fd\u91cf\u4ee3\u8c22\u7684\u91cd\u8981\u56e0\u5b50, \u5b83\u80fd\u591f\u4fc3\u8fdb\u7ebf\u7c92\u4f53\u7684\u751f\u957f\u53d1\u80b2, \u540c\u65f6\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u6297\u6c27\u5316\u6027, \u53ef\u6709\u6548\u6e05\u9664\u81ea\u7531\u57fa\u3001\u51cf\u5c11\u7ec6\u80de\u635f\u4f24[5\u20126]\u3002\u56e0\u6b64, PQQ \u5728\u6297\u708e\u3001\u8111\u5065\u5eb7\u3001\u514d\u75ab\u529b\u63d0\u5347\u3001\u5fc3\u8840\u7ba1\u5065\u5eb7\u548c\u6297\u75b2\u52b3\u7b49\u65b9\u9762\u90fd\u5177\u6709\u663e\u8457\u7684\u6548\u679c\u3002\u8fd1\u5e74\u6765, \u968f\u7740 PQQ\u7814\u7a76\u6df1\u5165\u53ca\u5728\u98df\u54c1\u4e2d\u5e94\u7528\u5f97\u5230\u5404\u56fd\u6cd5\u89c4\u652f\u6301, \u5176\u5df2\u5e94\u7528\u4e8e\u666e\u901a\u98df\u54c1\u3001\u81b3\u98df\u8865\u5145\u5242\u9886\u57df, \u76f8\u5173\u4ea7\u54c1\u4e0a\u5e02\u6570\u91cf\u9010\u5e74\u4e0a\u5347\u3002\u4f5c\u4e3a\u5929\u7136\u6297\u6c27\u5316\u5242\u548c\u7ebf\u7c92\u4f53\u529f\u80fd\u6539\u5584\u5242\u7684 PQQ \u5df2\u7ecf\u9010\u6b65\u88ab\u6d88\u8d39\u8005\u6240\u8ba4\u77e5, \u672a\u6765\u5e02\u573a\u524d\u666f\u826f\u597d\u3002\u8fd1\u5e74\u6765, \u5bf9\u4e8e PQQ \u7684\u529f\u80fd\u7279\u6027\u5df2\u6709\u76f8\u5bf9\u6210\u719f\u7684\u7814\u7a76, \u4f46\u9488\u5bf9 PQQ \u5728\u98df\u54c1\u9886\u57df\u7684\u6cd5\u89c4\u8fdb\u5c55\u53ca\u4ea7\u54c1\u5e94\u7528\u65b9\u9762\u7684\u7814\u7a76\u8f83\u5c11\u3002\u56e0\u6b64\u4e3a\u4e86\u6df1\u5165\u7814\u7a76PQQ \u7684\u529f\u80fd\u7279\u70b9, \u5bf9\u5176\u8fdb\u884c\u5408\u7406\u6709\u6548\u7684\u5f00\u53d1\u5e94\u7528, \u672c\u6587\u4e3b\u8981\u5bf9 PQQ \u7684\u7814\u7a76\u73b0\u72b6\u53ca\u5e94\u7528\u8fdb\u884c\u7efc\u8ff0, \u91cd\u70b9\u603b\u7ed3\u4e86 PQQ \u8fd1\u5e74\u6765\u7684\u5b89\u5168\u6027\u4e0e\u6cd5\u89c4\u8fdb\u5c55\u3001\u529f\u80fd\u7279\u6027\u53ca\u76ee\u524d\u56fd\u5185\u5916\u4ea7\u54c1\u5f00\u53d1\u73b0\u72b6, \u4ee5\u671f\u4e3a PQQ \u529f\u80fd\u6027\u4ea7\u54c1\u7684\u540e\u7eed\u5f00\u53d1\u548c\u5e94\u7528\u63d0\u4f9b\u53c2\u8003\u3002<\/p>\n\n\n\n
1 PQQ \u7684\u5b89\u5168\u6027\u53ca\u6cd5\u89c4\u73b0\u72b6<\/p>\n\n\n\n
PQQ \u5728\u56fd\u5185\u5916\u5e7f\u6cdb\u5e94\u7528\u4e8e\u81b3\u98df\u8865\u5145\u5242\u53ca\u529f\u80fd\u98df\u54c1, \u5176\u5b89\u5168\u6027\u5f97\u5230\u4e86\u56fd\u5185\u5916\u5927\u91cf\u5b66\u8005\u5f00\u5c55\u7684\u6bd2\u7406\u5b66\u8bd5\u9a8c\u9a8c\u8bc1\u3002\u738b\u4e3d\u4e91\u7b49[7]\u6309\u7167\u300a\u4fdd\u5065\u98df\u54c1\u68c0\u9a8c\u4e0e\u8bc4\u4ef7\u6280\u672f\u89c4\u8303\u300b\u4e2d\u76f8\u5173\u65b9\u6cd5\u5bf9 PQQ \u8fdb\u884c\u7814\u7a76\u540e\u53d1\u73b0, \u96cc\u96c4\u5c0f\u9f20\u6025\u6027\u7ecf\u53e3\u534a\u6570\u81f4\u6b7b\u91cf(median lethal dose, LD50)\u503c\u5206\u522b\u4e3a 3690 mg\/kg\u548c 2710 mg\/kg, \u6700\u5927\u65e0\u4f5c\u7528\u5242\u91cf(no observed adverse effect level, NOAEL)\u4e3a 15 mg\/kg, PQQ \u5c5e\u4f4e\u6bd2\u7269\u8d28, \u65e0\u660e\u663e\u81f4\u7a81\u53d8\u4f5c\u7528\u3002\u90dd\u798f\u661f\u7b49[8]\u7684\u7814\u7a76\u53d1\u73b0, \u5421\u54af\u55b9\u5549\u918c\u4e8c\u94a0\u5bf9\u5c0f\u9f20\u7684\u6025\u6027\u7ecf\u53e3 LD50\u4e3a 4027.82 mg\/kg, \u5c5e\u4e8e\u5b9e\u9645\u4f4e\u6bd2\u7269\u8d28, \u5728\u4e9a\u6162\u6027\u6bd2\u6027\u8bd5\u9a8c\u4e2d, \u5927\u9f20\u5747\u672a\u51fa\u73b0\u6bd2\u6027\u53cd\u5e94, NOAEL \u4e3a2000 mg\/kg\u3002\u53e6\u4e00\u9879\u901a\u8fc7\u5927\u9f20\u8fdb\u884c\u7684\u5421\u54af\u55b9\u5549\u918c\u4e8c\u94a0\u76d0\u4e9a\u6162\u6027\u53e3\u670d\u6bd2\u6027\u7814\u7a76\u53d1\u73b0[9], \u5176 NOAEL \u4e3a\u6bcf\u5929 400 mg\/kg\u3002\u5728\u5c0f\u9f20\u4f53\u5185\u5fae\u6838\u8bd5\u9a8c\u4e2d[10], 2000 mg\/kg \u4f53\u91cd\u5242\u91cf\u7684 PQQ \u5728\u9aa8\u9ad3\u7ea2\u7ec6\u80de\u4f53\u5185\u6ca1\u6709\u8868\u8fbe\u9057\u4f20\u6bd2\u6027\u4f5c\u7528\u3002\u591a\u9879\u7814\u7a76\u8868\u660e\u5728\u5408\u7406\u5242\u91cf\u4e0b PQQ \u7684\u5b89\u5168\u6027\u662f\u6709\u4fdd\u969c\u7684\u3002<\/p>\n\n\n\n
\u6839 \u636e \u7f8e \u56fd \u98df \u54c1 \u836f \u54c1 \u76d1 \u7763 \u7ba1 \u7406 \u5c40 (Food and Drug Administration, FDA) GRN000625 \u76f8\u5173\u516c\u544a\u53ca\u56de\u590d\u53ef\u77e5, 2016 \u5e74 8 \u6708, PQQ \u83b7\u5f97 FDA GRAS \u8ba4\u8bc1, \u53ef\u4f5c\u4e3a\u539f\u6599\u7528\u4e8e\u80fd\u91cf\u996e\u6599\u3001\u8fd0\u52a8\u996e\u6599\u3001\u7535\u89e3\u8d28\u996e\u6599\u4ee5\u53ca\u74f6\u88c5\u6c34\u7b49\u98df\u54c1, \u6bcf\u4efd\u4ea7\u54c1\u7684 PQQ \u6700\u5927\u542b\u91cf\u4e3a 8 mg[11]\u30022018 \u5e74 8 \u6708\u6b27\u76df\u59d4\u5458\u4f1a\u53d1\u5e03\u6cd5\u89c4(EU)2018\/1122, \u6279\u51c6\u4e09\u83f1\u74e6\u65af\u5316\u5b66\u682a\u5f0f\u4f1a\u793e\u7533\u8bf7\u7684\u5421\u54af\u55b9\u5549\u918c\u4e8c\u94a0\u76d0\u4f5c\u4e3a\u65b0\u578b\u98df\u54c1, \u53ef\u4ee5\u5e94\u7528\u4e8e\u5b55\u5987\u548c\u54fa\u4e73\u671f\u5987\u5973\u4ee5\u5916\u7684\u6210\u5e74\u4eba, \u6700\u5927\u7528\u91cf\u4e3a 20 mg\/d[12]\u30022021\u5e74 8 \u6708, \u56fd\u5bb6\u519c\u4e1a\u90e8\u6279\u51c6\u5421\u54af\u5e76\u55b9\u5549\u918c\u4e8c\u94a0\u53ef\u4ee5\u5e94\u7528\u4e8e\u8089\u4ed4\u9e21\u7684\u65b0\u9972\u6599\u6dfb\u52a0\u5242, \u5728\u914d\u5408\u9972\u6599\u4e2d\u7684\u63a8\u8350\u6dfb\u52a0\u91cf\u4e3a0.1~0.2 mg\/kg[13]\u30022021 \u5e74 3 \u6708\u8bf8\u57ce\u5e02\u6d69\u5929\u836f\u4e1a\u6709\u9650\u516c\u53f8\u7533\u62a5\u7684\u65b0\u98df\u54c1\u539f\u6599\u5421\u54af\u55b9\u5549\u918c\u4e8c\u94a0\u88ab\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u53d7\u7406, \u53d7\u7406\u7f16\u53f7\u4e3a\u536b\u98df\u65b0\u7533\u5b57(2021)\u7b2c 0004 \u53f7, 2022 \u5e74 3 \u6708\u88ab\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u6279\u51c6\u4e3a\u65b0\u98df\u54c1\u539f\u6599, \u53ef\u4ee5\u5e94\u7528\u4e8e\u9664\u5a74\u5e7c\u513f\u3001\u5b55\u5987\u53ca\u54fa\u4e73\u671f\u5987\u5973\u4ee5\u5916\u7684\u4eba\u7fa4, \u6bcf\u65e5\u98df\u7528\u91cf\u226420 mg\/d, \u5176\u751f\u4ea7\u5de5\u827a\u662f\u5316\u5b66\u5408\u6210\u6cd5, \u53ef\u5e94\u7528\u4e8e\u996e\u6599\u9886\u57df[14]\u30022023 \u5e742 \u6708 2 \u65e5, \u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u653f\u52a1\u5e73\u53f0\u53d1\u5e03\u5421\u54af\u55b9\u5549\u918c\u4e8c\u94a0\u76d0\u53d7\u7406\u516c\u544a, \u53d7\u7406\u7f16\u53f7: \u536b\u98df\u65b0\u7533\u5b57(2023)\u7b2c 0001 \u53f7,\u8fd9\u662f\u4ee5\u98df\u8461\u8404\u7cd6\u98df\u7532\u57fa\u83cc(Methylovorus glucosotrophus)\u4e3a\u83cc\u79cd\u53d1\u9175\u751f\u4ea7\u7684 PQQ[15], \u8be5\u53d1\u9175\u6cd5\u6765\u6e90\u7684 PQQ \u5df2\u4e8e 2023\u5e74 10 \u6708 7 \u65e5\u83b7\u5f97\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u6279\u51c6\u4f7f\u7528\u3002<\/p>\n\n\n\n
2 PQQ \u7684\u529f\u6548\u4f5c\u7528<\/p>\n\n\n\n
2.1 \u6539\u5584\u8ba4\u77e5\u529f\u80fd<\/p>\n\n\n\n
\u4eba\u53e3\u8001\u9f84\u5316\u7684\u52a0\u5267\u5bfc\u81f4\u8001\u5e74\u4eba\u7fa4\u8ba4\u77e5\u969c\u788d\u5448\u73b0\u9ad8\u53d1\u6001\u52bf, \u4e00\u9879\u7eb3\u5165 25 \u4e2a\u7814\u7a76\u7684 Meta \u5206\u6790\u53d1\u73b0[16], \u4e2d\u56fd\u8001\u5e74\u4eba\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u60a3\u75c5\u7387\u8f83\u9ad8, \u8fbe\u5230\u4e86 14%\u3002\u56e0\u6b64, \u5728\u8ba4\u77e5\u5065\u5eb7\u65b9\u9762\u7684\u5e72\u9884\u81f3\u5173\u91cd\u8981\u3002\u901a\u8fc7\u4f53\u5916\u7ec6\u80de\u8bd5\u9a8c\u53d1\u73b0 PQQ\u53ef\u4ee5\u51cf\u8f7b\u6c27\u5316\u5e94\u6fc0\u53cd\u5e94, \u964d\u4f4e\u7ec6\u80de\u51cb\u4ea1\u7387\u4ece\u800c\u5bf9\u6c27\u7cd6\u5265\u593a\u635f\u4f24\u7684 Neur02A \u7ec6\u80de\u8d77\u5230\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528[17]\u3002PQQ \u4e5f\u80fd\u591f\u7a33\u5b9a\u7ebf\u7c92\u4f53\u529f\u80fd\u3001\u51cf\u5c11 Ca2+\u8d85\u8f7d\u3001\u964d\u4f4e\u6d3b\u6027\u6c27(reactive oxygen species, ROS)\u5bf9\u673a\u4f53\u7684\u635f\u4f24\u5e76\u80fd\u591f\u589e\u52a0\u6297\u6c27\u5316\u57fa\u56e0\u7684\u8868\u8fbe\u4ece\u800c\u8d77\u5230\u5927\u8111\u7ec6\u80de\u4fdd\u62a4\u529f\u80fd\u7684\u4f5c\u7528[18]\u3002\u4e5f\u6709\u7814\u7a76\u53d1\u73b0 PQQ \u53ef\u4ee5\u63d0\u5347\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u6a21\u578b 5XFAD \u5c0f\u9f20\u8111\u4e2d\u7684\u7ebf\u7c92\u4f53\u529f\u80fd, \u964d\u4f4e ROS \u6c34\u5e73, \u663e\u8457\u6539\u5584 5XFAD \u5c0f\u9f20\u7684\u8fd0\u52a8\u7f3a\u9677\u548c\u8ba4\u77e5\u969c\u788d[19]\u3002<\/p>\n\n\n\n
PQQ \u80fd\u591f\u6539\u5584 D-\u534a\u4e73\u7cd6\u8bf1\u5bfc\u7684\u8ba4\u77e5\u635f\u4f24\u5c0f\u9f20\u6d77\u9a6c\u533a\u7684\u76f8\u5173\u6297\u6c27\u5316\u6307\u6807, \u589e\u5f3a\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176(superoxide dismutase, SOD)\u7684\u57fa\u56e0\u8868\u8fbe, \u964d\u4f4e\u78f7\u9178\u5316\u86cb\u767d\u6fc0\u9176(phosphorylated protein kinase B, p-AKT)\u7684\u8868\u8fbe, \u7ef4\u6301\u4e86\u7cd6\u539f\u5408\u6210\u9176\u6fc0\u9176(glycogen synthase kinase 3\u03b2, GSK-3\u03b2)\u7684\u6d3b\u6027, \u4ece\u800c\u5bfc\u81f4\u6d77\u9a6c\u533a\u78f7\u9178\u5316 Tau \u86cb\u767d(phosphorylatedmicrotubule associated protein tau, p-Tau)\u6c34\u5e73\u4e0b\u8c03[20]\u3002\u4e00\u9879\u7eb3\u5165\u4e86 20 \u540d 50~70 \u5c81\u4e4b\u95f4\u7684\u5065\u5eb7\u53d7\u8bd5\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u53d1\u73b0, 20 mg\/d \u7684 PQQ \u5e72\u9884 12 \u5468\u53ef\u4ee5\u589e\u5f3a\u524d\u989d\u53f6\u76ae\u5c42\u7684\u5c40\u90e8\u8111\u8840\u6d41\u91cf\u548c\u6c27\u4ee3\u8c22\u80fd\u529b, \u4ece\u800c\u63d0\u9ad8\u5927\u8111\u8ba4\u77e5\u529f\u80fd[21]\u3002\u53e6\u4e00\u9879\u5305\u542b 41 \u540d\u8001\u5e74\u5065\u5eb7\u53d7\u8bd5\u8005\u7684\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u53cc\u76f2\u8bd5\u9a8c, \u540c\u6837\u91c7\u7528 20 mg\/d \u7684 PQQ \u5e72\u9884 12 \u5468, \u4e5f\u53d1\u73b0\u53d7\u8bd5\u8005\u7684\u5927\u8111\u524d\u989d\u53f6\u76ae\u5c42\u7684\u8111\u8840\u6d41\u91cf\u663e\u8457\u589e\u52a0[22], \u663e\u793a PQQ \u53ef\u4ee5\u9884\u9632\u8001\u5e74\u4eba\u8111\u529f\u80fd\u51cf\u9000, \u5177\u6709\u63d0\u5347\u6ce8\u610f\u529b\u548c\u8bb0\u5fc6\u529b\u7684\u6f5c\u529b\u3002\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u5e73\u884c\u7ec4\u8bd5\u9a8c\u8bc4\u4f30\u4e86 58 \u540d40~80 \u5c81\u7684\u53d7\u8bd5\u8005, \u4ed6\u4eec\u6bcf\u5929\u63a5\u53d7\u5242\u91cf\u4e3a 21.5 mg PQQ\u300212\u5468\u540e, PQQ \u5e72\u9884\u7ec4\u5728 Cognitrax \u6d4b\u8bd5\u4e2d\u7684\u201c\u590d\u5408\u8bb0\u5fc6\u201d\u201c\u8bed\u8a00\u8bb0\u5fc6\u201d\u201c\u53cd\u5e94\u65f6\u95f4\u201d\u201c\u590d\u5408\u6ce8\u610f\u529b\u201d\u201c\u8ba4\u77e5\u7075\u6d3b\u6027\u201d\u201c\u6267\u884c\u529f\u80fd\u201d6\u4e2a\u7ef4\u5ea6\u7684\u8ba4\u77e5\u8bc4\u5206\u663e\u8457\u6539\u5584, \u8868\u660e PQQ \u6709\u52a9\u4e8e\u6539\u5584\u8bb0\u5fc6\u3001\u6ce8\u610f\u529b\u3001\u5224\u65ad\u548c\u8ba4\u77e5\u529f\u80fd[23]\u3002\u4e3a\u4e86\u8bc4\u4f30 PQQ \u5bf9\u4e0d\u540c\u5e74\u9f84\u4eba\u7fa4\u7684\u8ba4\u77e5\u76ca\u5904\u5dee\u5f02, \u53e6\u4e00\u9879\u7814\u7a76\u5c06\u53d7\u8bd5\u8005\u5206\u4e3a\u5e74\u8f7b\u7ec4(21~40 \u5c81)\u548c\u8001\u5e74\u7ec4(41~65 \u5c81), \u7ecf\u8fc7 20 mg\/d \u5242\u91cf\u5e72\u9884 12\u5468, Cognitrax \u8ba4\u77e5\u80fd\u529b\u6d4b\u8bd5\u7684\u5206\u6790\u7ed3\u679c\u663e\u793a, \u8001\u5e74\u7ec4\u7684\u8bed\u8a00\u8bb0\u5fc6\u548c\u590d\u5408\u8bb0\u5fc6\u6709\u6240\u6539\u5584, \u5e74\u8f7b\u7ec4\u6ca1\u6709\u663e\u8457\u6539\u5584, \u4f46\u53ef\u4ee5\u589e\u5f3a\u8ba4\u77e5\u7075\u6d3b\u6027\u548c\u6267\u884c\u901f\u5ea6[24]\u3002PQQ \u76ee\u524d\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528254 \u4e8e\u5927\u8111\u6539\u5584\u98df\u54c1, \u57fa\u4e8e\u5176\u5927\u91cf\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u5206\u6790, \u6444\u5165PQQ \u5bf9\u5404\u7c7b\u4eba\u7fa4\u5747\u53ef\u8d77\u5230\u8ba4\u77e5\u652f\u6301\u4f5c\u7528\u3002<\/p>\n\n\n\n
2.2 \u5bf9\u8fd0\u52a8\u4eba\u7fa4\u652f\u6301\u529f\u80fd<\/p>\n\n\n\n
PQQ \u6709\u7740\u8d85\u5f3a\u7684\u6297\u6c27\u5316\u53ca\u6297\u708e\u529f\u80fd\u800c\u83b7\u5f97\u8fd0\u52a8\u5065\u8eab\u4eba\u7fa4\u5e7f\u6cdb\u5173\u6ce8, \u76ee\u524d\u6709\u5927\u91cf\u7684\u7814\u7a76\u8bc1\u5b9e\u4e86 PQQ \u7684\u8fd0\u52a8\u635f\u4f24\u4fee\u590d\u4f5c\u7528\u3002\u8865\u5145 PQQ \u80fd\u6709\u6548\u6539\u5584\u5c0f\u9f20\u529b\u7aed\u8fd0\u52a8\u6240\u81f4\u7684\u5fc3\u808c\u635f\u4f24, \u663e\u8457\u964d\u4f4e\u4e19\u4e8c\u919b(malondialdehyde, MDA)\u542b\u91cf, \u589e\u52a0 SOD \u548c\u8c37\u80f1\u7518\u80bd\u8fc7\u6c27\u5316\u7269\u9176(glutathione peroxidase, GSH-Px)\u6d3b\u6027, \u964d\u4f4e\u8840\u6e05\u5fc3\u578b\u808c\u9178\u6fc0\u9176(creatine kinase-MB, CK-MB)\u548c\u808c\u9499\u86cb\u767d I (cardiac troponin I, c Tn-I)\u6807\u5fd7\u7269\u6c34\u5e73, \u540c\u65f6\u6291\u5236\u7ec6\u80de\u51cb\u4ea1\u4fdd\u62a4\u5fc3\u808c\u7ec6\u80de, \u8bc1\u660e PQQ \u5bf9\u8fd0\u52a8\u8bf1\u5bfc\u7684\u6c27\u5316\u5e94\u6fc0\u548c\u8fc7\u6c27\u5316\u635f\u4f24\u5177\u6709\u4fdd\u62a4\u4f5c\u7528[25]\u3002\u9488\u5bf9\u8499\u53e4\u8d5b\u9a6c\u7684\u5e72\u9884\u8bd5\u9a8c\u53d1\u73b0\u8865\u5145\u9972\u5582 PQQ 25 mg\/d, \u663e\u8457\u63d0\u9ad8\u8d5b\u9a6c\u8840\u6db2\u4e2d\u777e\u916e(testosterone, T)\u3001\u76ae\u8d28\u9187(cortisol, COR)\u6d53\u5ea6\u548c\u8840\u6db2\u4e2d\u808c\u9178\u6fc0\u9176(creatine kinase, CK)\u6d3b\u6027, \u63d0\u9ad8\u8d5b\u9a6c\u7684\u8fd0\u52a8\u6027\u80fd, \u540c\u65f6\u663e\u8457\u63d0\u9ad8 SOD \u548c\u8fc7\u6c27\u5316\u6c22\u9176(catalase, CAT)\u57fa\u56e0\u7684\u8868\u8fbe\u91cf, \u53ef\u4ee5\u6709\u6548\u7f13\u89e3\u8d5b\u9a6c\u808c\u8089\u75b2\u52b3\u548c\u8fd0\u52a8\u635f\u4f24[26]\u3002<\/p>\n\n\n\n
PQQ \u5728\u4f53\u5185\u3001\u4f53\u5916\u8fd0\u52a8\u6027\u75b2\u52b3\u6a21\u578b\u4e2d, \u8868\u73b0\u51fa\u6297\u6c27\u5316\u5e94\u6fc0\u3001\u51cf\u8f7b\u6838\u56e0\u5b50 \u03baB (nuclear factor kappa-B, NF-\u03baB)\u4ecb\u5bfc\u7684\u708e\u75c7\u53cd\u5e94, \u6297\u7ec4\u7ec7\u635f\u4f24, \u4fdd\u6301\u8840\u6e05\u6b63\u5e38\u7684\u4ee3\u8c22\u6c34\u5e73, \u5177\u6709\u7ef4\u6301\u7ebf\u7c92\u4f53\u6b63\u5e38\u5f62\u6001\u548c\u529f\u80fd\u7684\u4f5c\u7528, \u8fdb\u800c\u9884\u9632\u4e0e\u5ef6\u7f13\u4e86\u8fd0\u52a8\u6027\u75b2\u52b3\u7684\u53d1\u751f[27]\u3002\u5728\u6a21\u62df\u9ad8\u539f\u4f4e\u6c27\u6761\u4ef6\u4e0b, PQQ \u80fd\u591f\u51cf\u8f7b\u5c0f\u9f20\u4f4e\u538b\u4f4e\u6c27\u4e0b\u7684\u6c27\u5316\u5e94\u6fc0\u635f\u4f24, \u5176\u63d0\u5347\u8fd0\u52a8\u80fd\u529b\u7684\u5206\u5b50\u673a\u5236\u53ef\u80fd\u4e0e\u5176\u8c03\u63a7\u5fc3\u810f\u7ebf\u7c92\u4f53\u751f\u7269\u53d1\u751f\u3001\u7ebf\u7c92\u4f53\u878d\u5408-\u5206\u88c2\u52a8\u6001\u5e73\u8861\u3001\u7ebf\u7c92\u4f53\u6c27\u5316\u5e94\u6fc0\u548c\u80fd\u91cf\u4ee3\u8c22\u76f8\u5173[28]\u3002\u7f8e\u56fd\u739b\u4e3d\u54c8\u4e01-\u8d1d\u52d2\u5927\u5b66\u7684 Willoughby DS \u6559\u6388\u56e2\u961f\u5f00\u5c55\u4e86\u4e00\u9879\u7eb3\u5165 23 \u540d\u7537\u6027\u7684\u7814\u7a76, \u5e72\u9884\u7ec4\u6bcf\u5929\u670d\u7528 20 mg PQQ, \u540c\u65f6\u63a5\u53d7\u4e86\u4e3a\u671f 6\u5468\u7684\u8010\u529b\u8fd0\u52a8\u8bad\u7ec3\u540e, \u5176\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u7269\u6fc0\u6d3b\u53d7\u4f53 \u03b3 \u5171\u6fc0\u6d3b\u56e0\u5b50-1\u03b1 (peroxisome proliferator-activated receptor \u03b3 coactiva-tor-1\u03b1, PGC-1\u03b1)\u6c34\u5e73\u663e\u8457\u5347\u9ad8, \u663e\u793a PQQ \u63d0\u5347\u4e86\u7ebf\u7c92\u4f53\u751f\u7269\u53cd\u5e94\u80fd\u529b[29]\u3002\u5927\u91cf\u7684\u8bd5\u9a8c\u90fd\u8bc1\u5b9e\u4e86 PQQ \u80fd\u6539\u5584\u6c27\u5316\u538b\u529b, \u964d\u4f4e\u708e\u75c7\u6307\u6807, \u53ef\u89c1 PQQ \u5728\u63d0\u5347\u8fd0\u52a8\u673a\u80fd\u65b9\u9762\u6709\u7740\u79ef\u6781\u7684\u6548\u679c, \u53ef\u4ee5\u4f5c\u4e3a\u63d0\u5347\u8fd0\u52a8\u80fd\u529b\u7684\u81b3\u98df\u8865\u5145\u5242\u3002<\/p>\n\n\n\n
2.3 \u9aa8\u8d28\u758f\u677e\u4fee\u590d\u4f5c\u7528<\/p>\n\n\n\n
\u9aa8\u8d28\u758f\u677e\u75c7\u5df2\u7ecf\u6210\u4e3a\u4e25\u91cd\u5a01\u80c1\u8001\u5e74\u4eba\u5065\u5eb7\u7684\u75be\u75c5\u4e4b\u4e00, 2018 \u5e74\u6211\u56fd 65 \u5c81\u4ee5\u4e0a\u4eba\u7fa4\u9aa8\u8d28\u758f\u677e\u75c7\u60a3\u75c5\u7387\u4e3a 32%, \u7537\u6027\u4e3a 10.7%, \u5973\u6027\u4e3a 51.6%[30]\u3002\u4f53\u5916\u8bd5\u9a8c\u53d1\u73b0 PQQ \u53ef\u4ee5\u4fc3\u8fdb\u5154\u819d\u5173\u8282\u8f6f\u9aa8\u7ec6\u80de\u7684\u5206\u88c2\u589e\u6b96, \u5bf9\u767d\u7ec6\u80de\u4ecb\u7d20-1\u03b2 (interleukin-1\u03b2, IL-1\u03b2)\u4ecb\u5bfc\u7684\u8f6f\u9aa8\u7ec6\u80de\u51cb\u4ea1\u5177\u6709\u660e\u663e\u6291\u5236\u4f5c\u7528[31]\u3002PQQ \u4e5f\u53ef\u4ee5\u4f7f\u5c0f\u9f20\u80eb\u9aa8\u5f62\u6001\u589e\u52a0, \u660e\u663e\u63d0\u9ad8\u5176\u9aa8\u5bc6\u5ea6\u3001\u76ae\u8d28\u9aa8\u539a\u5ea6\u3001\u751f\u957f\u677f\u5bbd\u5ea6\u3001\u9aa8\u5c0f\u6881\u8d28\u91cf, PQQ \u6297\u9aa8\u8d28\u758f\u677e\u662f\u901a\u8fc7\u4e0a\u8c03\u5c0f\u9f20\u6297\u6c27\u5316\u80fd\u529b\u3001\u6291\u5236\u6c27\u5316\u5e94\u6fc0\u548c\u51cf\u5c11DNA \u635f\u4f24\u3001\u4e0b\u8c03\u5468\u671f\u7d20\u4f9d\u8d56\u6027\u6fc0\u9176\u6291\u5236\u56e0\u5b50\u86cb\u767d\u6c34\u5e73\u3001\u51cf\u5c11\u7ec6\u80de\u51cb\u4ea1[32]\u3002\u6027\u6fc0\u7d20\u5206\u6ccc\u51cf\u5c11\u4e5f\u662f\u8001\u5e74\u4eba\u7fa4\u9aa8\u8d28\u758f\u677e\u75c7\u9ad8\u53d1\u7684\u539f\u56e0\u4e4b\u4e00, PQQ \u901a\u8fc7\u6291\u5236\u6c27\u5316\u5e94\u6fc0, \u51cf\u5c11 DNA \u635f\u4f24\u548c\u7ec6\u80de\u51cb\u4ea1, \u4fc3\u8fdb\u9aa8\u9ad3\u57fa\u8d28\u5e72\u7ec6\u80de\u589e\u6b96\u5206\u5316\u4e3a\u6210\u9aa8\u7ec6\u80de, \u5e76\u901a\u8fc7\u6291\u5236\u9aa8 NF-\u03baB \u4fe1\u53f7\u901a\u8def\u51cf\u5c11\u7834\u9aa8\u7ec6\u80de\u9aa8\u5438\u6536, \u53ef\u4ee5\u9884\u9632\u777e\u916e\u7f3a\u4e4f\u8bf1\u5bfc\u7684\u9aa8\u8d28\u758f\u677e\u75c7\u7684\u53d1\u751f\u53d1\u5c55[33]\u3002\u53e6\u4e00\u7814\u7a76\u53d1\u73b0, PQQ \u901a\u8fc7\u6291\u5236\u6c27\u5316\u5e94\u6fc0\u3001\u964d\u4f4e\u9aa8\u7ec6\u80de\u8870\u8001\u548c\u8870\u8001\u76f8\u5173\u7684\u5206\u6ccc\u8868\u578b(senescence-associated secretory phenotype, SASP), \u8fdb\u800c\u4fc3\u8fdb\u6210\u9aa8\u7ec6\u80de\u9aa8\u5f62\u6210\u548c\u6291\u5236\u7834\u9aa8\u7ec6\u80de\u9aa8\u5438\u6536, \u9632\u6b62\u53bb\u5375\u5de2\u8bf1\u5bfc\u7684\u9aa8\u4e22\u5931\u5e76\u63d0\u9ad8\u96cc\u6fc0\u7d20\u7f3a\u4e4f\u5c0f\u9f20\u9aa8\u5f3a\u5ea6, \u663e\u793a PQQ \u53ef\u7528\u4e8e\u9632\u6cbb\u7edd\u7ecf\u540e\u9aa8\u8d28\u758f\u677e\u75c7, \u5176\u6548\u679c\u4e0e\u4f7f\u7528\u5916\u6e90\u6027\u96cc\u6fc0\u7d20\u6cbb\u7597\u76f8\u5f53[34]\u3002\u90d1\u9e4f\u9aa5\u7b49[35]\u53d1\u73b0 PQQ \u901a\u8fc7\u6291\u5236\u6c27\u5316\u5e94\u6fc0\u548c\u6539\u5584\u6838\u56e0\u5b50 \u03baB \u53d7\u4f53\u6d3b\u5316\u56e0\u5b50\u914d\u4f53\/\u9aa8\u4fdd\u62a4\u7d20(receptor activator of nuclear kappa-B\/osteoprotegerin, RANKL\/OPG)\u6bd4\u7387, \u589e\u52a0\u9aa8\u91cf\u548c\u9aa8\u5f3a\u5ea6, \u663e\u8457\u6539\u5584\u96cc\u6fc0\u7d20\u7f3a\u4e4f\u5f15\u8d77\u7684\u9aa8\u8d28\u758f\u677e\u75c7\u3002\u591a\u9879\u7814\u7a76\u8868\u660e, PQQ \u6709\u6cbb\u7597\u6027\u6fc0\u7d20\u7f3a\u4e4f\u5f15\u8d77\u7684\u9aa8\u8d28\u758f\u677e\u75c7\u7684\u6f5c\u529b\u3002<\/p>\n\n\n\n
2.4 \u4fdd\u809d\u4f5c\u7528<\/p>\n\n\n\n
\u6839\u636e 2018 \u5e74\u4e2d\u534e\u533b\u5b66\u4f1a\u809d\u75c5\u5b66\u5206\u4f1a\u5e74\u4f1a\u4e0a\u5e84\u8f89\u9662\u58eb\u53d1\u5e03\u7684\u6570\u636e, \u5168\u56fd\u5404\u7c7b\u809d\u75c5\u60a3\u8005\u7ea6 4 \u4ebf\u4eba, \u5176\u4e2d\u9152\u7cbe\u6027\u809d\u75c5\u5360 15.0%, \u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\u5360\u6bd4\u8fbe\u5230 50.0%, \u809d\u75c5\u5df2\u7ecf\u6210\u4e3a\u4e00\u4e2a\u4e25\u91cd\u7684\u516c\u5171\u536b\u751f\u95ee\u9898\u3002\u6709\u7814\u7a76\u53d1\u73b0[36], \u8865\u5145PQQ \u80fd\u591f\u964d\u4f4e\u996e\u98df\u8bf1\u5bfc\u80a5\u80d6\u7684\u598a\u5a20\u5c0f\u9f20\u540e\u4ee3\u809d\u810f\u4e2d\u795e\u7ecf\u9170\u80fa\u6c34\u5e73\u3001\u6c27\u5316\u5e94\u6fc0\u548c\u4fc3\u708e\u57fa\u56e0\u8868\u8fbe, \u540c\u65f6\u4f53\u8102\u548c\u809d\u810f\u8102\u8d28\u4e5f\u663e\u8457\u964d\u4f4e, \u663e\u793a PQQ \u6709\u52a9\u4e8e\u4fdd\u62a4\u996e\u98df\u8bf1\u5bfc\u80a5\u80d6\u540e\u4ee3\u514d\u53d7\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u7684\u5f71\u54cd\u3002PQQ \u4e5f\u53ef\u4ee5\u901a\u8fc7\u6fc0\u6d3b\u6838\u56e0\u5b50E2 \u76f8\u5173\u56e0\u5b50 2 (nuclear factor erythroid 2 related factor 2, Nrf2)\u4ecb\u5bfc\u7684\u4fe1\u53f7\u901a\u8def, \u51cf\u8f7b\u6c27\u5316\u5e94\u6fc0, \u4e0b\u8c03 Toll \u6837\u53d7\u4f53 4 (toll-like receptor 4, TLR4)\u4ecb\u5bfc\u7684\u708e\u6027\u53cd\u5e94\u8868\u8fbe, \u4ece\u800c\u6291\u5236\u9152\u7cbe\u8bf1\u5bfc\u7684\u708e\u75c7, \u964d\u4f4e\u8840\u6e05\u8c37\u4e19\u8f6c\u6c28\u9176\u53ca\u8c37\u8349\u8f6c\u6c28\u9176, \u63d0\u9ad8\u809d\u810f\u4e2d\u6297\u6c27\u5316\u9176\u7cfb\u7684\u6c34\u5e73, \u663e\u8457\u6539\u5584\u6025\u6027\u9152\u7cbe\u6027\u809d\u635f\u4f24[37]\u3002\u53e6\u6709\u8bd5\u9a8c\u8bc1\u5b9e[38], PQQ \u4e5f\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u6cdb\u7d20\u8fde\u63a5\u9176 3 (cullin-3, CUL3)\u7684\u8868\u8fbe\u6765\u51cf\u8f7b\u8113\u6bd2\u8840\u75c7\u5927\u9f20\u7684\u6025\u6027\u809d\u635f\u4f24\u53ca\u809d\u7ec4\u7ec7\u7ec6\u80de\u8c03\u4ea1\u3002PQQ \u901a\u8fc7\u589e\u5f3a\u673a\u4f53\u6297\u6c27\u5316\u80fd\u529b, \u964d\u4f4e\u81ea\u7531\u57fa\u7684\u6c34\u5e73, \u51cf\u8f7b\u809d\u7ea4\u7ef4\u5316\u5927\u9f20\u809d\u810f\u80f6\u539f\u7ea4\u7ef4\u589e\u751f\u7a0b\u5ea6[39]\u3002PQQ \u8fd8\u53ef\u4ee5\u964d\u4f4e\u8102\u8d28\u4ee3\u8c22\u7d0a\u4e71\u5bfc\u81f4\u7684\u809d\u635f\u4f24\u7a0b\u5ea6[40]\u3002\u53e6\u6709\u7814\u7a76\u53d1\u73b0[41], PQQ \u663e\u8457\u6539\u5584\u5c0f\u9f20\u809d\u810f\u6297\u6c27\u5316\u7cfb\u7edf\u51cf\u8f7b\u9549\u8bf1\u5bfc\u9020\u6210\u7684\u6025\u6027\u809d\u635f\u4f24\u3002<\/p>\n\n\n\n
2.5 \u5176\u4ed6\u4f5c\u7528<\/p>\n\n\n\n
\u7eb3\u5165 10 \u540d\u53d7\u8bd5\u8005\u7684\u4e24\u9879\u72ec\u7acb\u4ea4\u53c9\u7814\u7a76\u53d1\u73b0, \u8865\u5145PQQ \u540e\u53ef\u4ee5\u63d0\u5347\u7ebf\u7c92\u4f53\u6548\u7387, \u964d\u4f4e\u76f8\u5173\u708e\u75c7\u56e0\u5b50, \u63d0\u5347\u673a\u4f53\u6297\u6c27\u5316\u80fd\u529b[42]\u3002\u4e00\u9879\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u8bd5\u9a8c\u7eb3\u5165\u4e86 29 \u540d 40~57 \u5c81\u4e4b\u95f4\u7684\u5065\u5eb7\u53d7\u8bd5\u8005, \u7ecf\u8fc7 20 mg\/d \u7684 PQQ\u5e72\u9884 12 \u5468\u540e PQQ \u7ec4\u7684\u5e73\u5747\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\u6c34\u5e73\u663e\u8457\u4e0b\u964d, \u8840\u6e05\u5c3f\u9178\u6c34\u5e73\u4e5f\u663e\u8457\u964d\u4f4e[43]\u3002PQQ \u53ef\u4ee5\u901a\u8fc7\u589e\u52a0\u7ebf\u7c92\u4f53 Na+\/Ca2+\u4ea4\u6362\u4f53(mitochondrial Na+\/Ca2+ exchanger, NCLX)\u7684\u8868\u8fbe\u6765\u8c03\u8282\u7ec6\u80de\u5185\u9499\u79bb\u5b50\u6d53\u5ea6, \u51cf\u5c11 ROS \u7684\u4ea7\u751f, \u540c\u65f6\u53ef\u4ee5\u901a\u8fc7\u4e0a\u8c03\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u7269\u6d3b\u5316\u53d7\u4f53 \u03b3 \u5171\u6fc0\u6d3b\u56e0\u7b2c 22 \u671f \u674e\u4e2d\u67f1, \u7b49: \u5421\u54af\u55b9\u5549\u918c\u529f\u80fd\u7279\u6027\u53ca\u5176\u4ea7\u54c1\u7814\u7a76\u8fdb\u5c55 255 \u5b501-\u03b1 (peroxisome proliferator-activated receptor \u03b3 coactiva-tor-1\u03b1, p GC-1\u03b1)\u548c\u7ebf\u7c92\u4f53\u8f6c\u5f55\u56e0\u5b50 A (mitochondrial transcription factor A, TFAM), \u6539\u5584\u7ebf\u7c92\u4f53\u7684\u751f\u7269\u53d1\u751f\u548c\u9632\u6b62\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d, \u9884\u9632\u5fc3\u529b\u8870\u7aed[44]\u3002\u5bf9 22 \u540d\u5065\u5eb7\u5973\u6027\u53d7\u8bd5\u8005\u5e72\u9884\u8bd5\u9a8c\u53d1\u73b0, PQQ \u53ef\u4ee5\u663e\u8457\u6291\u5236\u624b\u524d\u81c2\u7ecf\u76ae\u6c34\u5206\u6563\u5931, \u51cf\u5c11\u76b1\u7eb9\u548c\u8272\u7d20\u6c89\u7740\u7684\u51fa\u73b0, \u6539\u5584\u76ae\u80a4\u72b6\u6001[45]\u3002\u514d\u75ab\u4f4e\u4e0b\u5c0f\u9f20\u6444\u5165 PQQ \u540e\u53ef\u4ee5\u4fee\u590d\u53d7\u635f\u7684\u813e\u810f, \u6fc0\u6d3b\u5176\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176(mitogen-activated protein kinase, MAPK)\u548c NF-\u03baB \u4fe1\u53f7\u901a\u8def\u4e2d\u76f8\u5173\u86cb\u767d\u7684\u8868\u8fbe, \u4f7f\u5f97\u5404\u9879\u514d\u75ab\u6307\u6807\u5f97\u5230\u6062\u590d, \u540c\u65f6\u7ef4\u6301\u80a0\u9053\u5fae\u751f\u7269\u5e73\u8861[46]\u3002\u7efc\u4e0a\u53ef\u4ee5\u53d1\u73b0, PQQ \u4f17\u591a\u7684\u529f\u6548\u4f5c\u7528\u968f\u7740\u7814\u7a76\u7684\u4e0d\u65ad\u6df1\u5165\u6b63\u5728\u9010\u6e10\u663e\u73b0, \u529f\u6548\u7684\u591a\u5143\u6027\u4e5f\u4f7f\u5f97\u5176\u5e94\u7528\u573a\u666f\u591a\u6837\u3002<\/p>\n\n\n\n
3 PQQ \u7684\u5f00\u53d1\u73b0\u72b6\u53ca\u53d1\u5c55\u524d\u666f<\/p>\n\n\n\n
\u5c3d\u7ba1\u56fd\u5185 PQQ \u4e8e 2022 \u5e74 3 \u6708\u5df2\u7ecf\u83b7\u5f97\u6279\u51c6, \u4f46\u5e02\u573a\u4e0a\u4ea7\u54c1\u6570\u91cf\u5f88\u6709\u9650, \u8fd9\u53ef\u80fd\u662f\u56e0\u4e3a\u76ee\u524d PQQ \u539f\u6599\u5355\u4ef7\u8f83\u9ad8\u53ca\u6d88\u8d39\u8005\u5bf9 PQQ \u8ba4\u77e5\u5ea6\u8fd8\u4e0d\u9ad8, \u56fd\u5185\u5e02\u573a\u4e0a\u4e3b\u8981\u4ee5\u56fa\u4f53\u996e\u6599\u7684\u5f62\u5f0f\u51fa\u73b0, \u9664\u4e86\u542b\u6709\u4e3b\u8981\u6210\u5206 PQQ \u5916, \u8fd8\u4f1a\u6dfb\u52a0\u5176\u4ed6\u529f\u80fd\u6027\u7684\u6210\u5206\u8fdb\u884c\u590d\u914d, \u4e00\u822c\u4e3a\u5c0f\u5242\u91cf\u7684\u51b2\u996e\u4ea7\u54c1\u3002PQQ \u76f8\u5173\u81b3\u98df\u8865\u5145\u5242\u4e3b\u8981\u96c6\u4e2d\u5728\u8111\u5065\u5eb7\u3001\u52a9\u7720\u3001\u80fd\u91cf\u8865\u5145\u3001\u53e3\u670d\u7f8e\u5bb9\u3001\u52a9\u5b55\u7b49\u529f\u80fd\u65b9\u9762, PQQ \u5728\u6d77\u5916\u5e02\u573a\u5e38\u7528\u4e8e\u80fd\u91cf\u996e\u6599\u3001\u8fd0\u52a8\u996e\u6599\u3001\u7535\u89e3\u8d28\u996e\u6599\u548c\u8425\u517b\u8865\u5145\u5242\u7b49\u9886\u57df, \u8fd9\u4e9b\u4ea7\u54c1\u5e38\u5e38\u4f1a\u4e0e\u76ca\u751f\u83cc\u3001\u03b2-\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178(nicotinamide mononucleotide, NMN)\u3001\u8f85\u9176 Q10\u3001\u94f6\u674f\u53f6\u63d0\u53d6\u7269\u53ca\u5404\u7c7b\u7ef4\u751f\u7d20\u7b49\u529f\u80fd\u539f\u6599\u914d\u5408\u4f7f\u7528\u3002\u7531\u4e8e\u56fd\u5916\u5bf9 PQQ \u7684\u5065\u5eb7\u529f\u6548\u548c\u529f\u80fd\u7279\u6027\u7814\u7a76\u8f83\u591a\u4e14\u8d77\u6b65\u8f83\u65e9, \u56e0\u6b64 PQQ \u5e7f\u6cdb\u7528\u4e8e\u666e\u901a\u98df\u54c1\u53ca\u81b3\u98df\u8865\u5145\u5242, \u56fd\u5185\u76f8\u5173\u4ea7\u54c1\u548c\u5e94\u7528\u4ecd\u5c5e\u4e8e\u8d77\u6b65\u53d1\u5c55\u9636\u6bb5\u3002<\/p>\n\n\n\n
\u4ece\u8868 1 \u4e2d\u4e5f\u53ef\u4ee5\u53d1\u73b0\u56fa\u4f53\u996e\u6599\u548c\u80f6\u56ca\u662f\u5e02\u573a\u4e0a\u6700\u591a\u7684\u5242\u578b, PQQ \u4f5c\u4e3a\u4e00\u4e2a\u9002\u4e8e\u590d\u914d\u7684\u529f\u80fd\u6027\u539f\u6599, \u76ee\u524d\u5404\u54c1\u7c7b\u4ea7\u54c1\u529f\u80fd\u805a\u7126\u4e8e\u7ebf\u7c92\u4f53\u4f18\u5316\u3001\u8865\u8111\u3001\u7f13\u89e3\u4f53\u529b\u75b2\u52b3\u3001\u7f8e\u5bb9\u7b49\u65b9\u9762, \u5927\u91cf\u7684 PQQ \u4ea7\u54c1\u8fd8\u662f\u4ee5\u81b3\u98df\u8865\u5145\u5242\u7684\u5f62\u5f0f\u5b58\u5728\u4e8e\u7ec8\u7aef\u5e02\u573a, \u7279\u522b\u662f\u7535\u5546\u5e73\u53f0\u7684\u8de8\u5883\u4ea7\u54c1\u3002<\/p>\n\n\n\n
\u7531\u88682\u53ef\u77e5\u8fd1\u5e74\u6765\u968f\u7740PQQ\u5728\u5404\u56fd\u6cd5\u89c4\u5730\u4f4d\u7684\u660e\u786e, \u76f8\u5173\u4ea7\u54c1\u4e13\u5229\u7684\u7533\u8bf7\u5728\u7a33\u6b65\u589e\u957f, \u5e94\u7528\u573a\u666f\u4e5f\u5728\u4e0d\u65ad\u6269\u5927, \u968f\u7740 PQQ \u76f8\u5173\u4ea7\u54c1\u53ca\u5176\u529f\u80fd\u6027\u7684\u7814\u7a76\u8fdb\u4e00\u6b65\u6df1\u5165, \u66f4\u591a\u7684\u539f\u6599\u5546\u7533\u8bf7\u6cd5\u89c4\u6269\u5927\u5e94\u7528\u8303\u56f4\u540e, \u5e02\u573a\u4e0a\u4f1a\u51fa\u73b0\u66f4\u591a\u4ea7\u54c1\u7c7b\u578b, \u672a\u6765 PQQ \u5728\u8425\u517b\u4fdd\u5065\u9886\u57df\u4e2d\u7684\u5e02\u573a\u524d\u666f\u5fc5\u5c06\u66f4\u52a0\u5e7f\u9614\u3002<\/p>\n\n\n\n![\"\"](\"https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2023\/12\/image-2.png\")
<\/figure>\n\n\n\n4 \u7ed3\u675f\u8bed<\/p>\n\n\n\n
\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u98df\u54c1\u539f\u6599, PQQ<\/a> \u5728\u4f18\u5316\u7ebf\u7c92\u4f53\u529f\u80fd\u3001\u63d0\u9ad8\u5927\u8111\u8ba4\u77e5\u80fd\u529b\u3001\u652f\u6301\u8fd0\u52a8\u80fd\u529b\u3001\u4fdd\u62a4\u809d\u810f\u3001\u6539\u5584\u9aa8\u8d28\u758f\u677e\u548c\u8c03\u8282\u708e\u75c7\u65b9\u9762\u5df2\u7ecf\u79ef\u7d2f\u4e86\u5927\u91cf\u7684\u8bd5\u9a8c\u8bc1\u636e, \u00a0\u968f\u7740 PQQ\u5b89\u5168\u6027\u5f97\u5230\u786e\u8ba4, \u00a0\u56fd\u5185\u6cd5\u89c4\u6279\u51c6\u4e86\u5408\u6210\u6cd5\u548c\u53d1\u9175\u6cd5\u6765\u6e90\u7684PQQ, \u00a0\u76f8\u5173 PQQ \u529f\u80fd\u98df\u54c1\u7684\u5f00\u53d1\u4e0e\u5e94\u7528\u6b63\u5728\u7a33\u6b65\u589e\u957f\u3002\u76ee\u524d, \u00a0\u56fd\u5185\u5e02\u573a\u4e0a\u5df2\u7ecf\u6709\u90e8\u5206\u542b PQQ \u7684\u529f\u80fd\u98df\u54c1, \u00a0\u4f46\u662f\u73b0\u9636\u6bb5 PQQ \u5e94\u7528\u53ca\u6d88\u8d39\u5e02\u573a\u8fd8\u662f\u96c6\u4e2d\u5728\u6b27\u7f8e\u5e02\u573a\u3002\u968f\u7740 PQQ\u7684\u7279\u6027\u4e0e\u529f\u80fd\u673a\u5236\u7814\u7a76\u7684\u4e0d\u65ad\u6df1\u5165, \u00a0\u4ee5\u53ca\u5176\u751f\u4ea7\u5de5\u827a\u6280\u672f\u7684\u5b8c\u5584\u4e0e\u63d0\u5347, \u00a0\u672a\u6765\u9700\u8981\u8fdb\u4e00\u6b65\u964d\u4f4e PQQ \u751f\u4ea7\u6210\u672c\u548c\u63d0\u5347\u6d88\u8d39\u8005\u8ba4\u77e5, \u00a0\u4ee5\u671f\u83b7\u5f97\u5e02\u573a\u5e7f\u6cdb\u5e94\u7528\u3002\u5728\u529f\u80fd\u4ea7\u54c1\u5f00\u53d1\u65b9\u5411, \u00a0\u9664\u4e86\u5355\u4e00 PQQ \u6210\u5206\u5916, \u00a0\u53ef\u4ee5\u8003\u8651 PQQ \u4e0e\u591a\u79cd\u529f\u80fd\u7269\u8d28\u53ca\u8425\u517b\u7d20\u590d\u914d\u4f7f\u7528, \u00a0\u62d3\u5c55\u66f4\u591a\u7684\u529f\u80fd\u548c\u6d88\u8d39\u573a\u666f\u3002\u76f8\u4fe1\u968f\u7740\u5e02\u573a\u8ba4\u77e5\u5ea6\u7684\u4e0d\u65ad\u52a0\u6df1, \u00a0PQQ \u5728\u529f\u80fd\u98df\u54c1\u9886\u57df\u4e2d\u62e5\u6709\u5de8\u5927\u7684\u5e94\u7528\u6f5c\u529b\u53ca\u5546\u4e1a\u4ef7\u503c\u3002<\/p>\n\n\n\n<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
\u674e\u4e2d\u67f11,2, \u6768\u6d0b1,2* \u6458\u8981\uff1a\u5421\u54af\u55b9\u5549\u918c\u4f5c\u4e3a\u4e00\u79cd\u6c27\u5316\u8fd8\u539f\u9176\u7684\u8f85\u9176, \u00a0\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u79cd\u751f\u7269\u4f53\u7ec4 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[12],"tags":[],"class_list":["post-193","post","type-post","status-publish","format-standard","hentry","category-12"],"yoast_head":"\n
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