{"id":856,"date":"2026-07-31T11:09:33","date_gmt":"2026-07-31T03:09:33","guid":{"rendered":"https:\/\/shandong.nugene.com.cn\/?p=856"},"modified":"2026-07-31T11:09:35","modified_gmt":"2026-07-31T03:09:35","slug":"nad%e2%81%bapqq-%e5%a4%8d%e5%90%88%e8%90%a5%e5%85%bb%e4%ba%a7%e5%93%81%e7%99%bd%e7%9a%ae%e4%b9%a6%ef%bd%9c%e8%82%9d%e7%bb%86%e8%83%9e%e4%bb%a3%e8%b0%a2%e4%b8%8e%e7%ba%bf%e7%b2%92%e4%bd%93%e5%85%bb","status":"publish","type":"post","link":"https:\/\/shandong.nugene.com.cn\/index.php\/nad%e2%81%bapqq-%e5%a4%8d%e5%90%88%e8%90%a5%e5%85%bb%e4%ba%a7%e5%93%81%e7%99%bd%e7%9a%ae%e4%b9%a6%ef%bd%9c%e8%82%9d%e7%bb%86%e8%83%9e%e4%bb%a3%e8%b0%a2%e4%b8%8e%e7%ba%bf%e7%b2%92%e4%bd%93%e5%85%bb\/","title":{"rendered":"NAD\u207a+PQQ \u590d\u5408\u8425\u517b\u4ea7\u54c1\u767d\u76ae\u4e66\uff5c\u809d\u7ec6\u80de\u4ee3\u8c22\u4e0e\u7ebf\u7c92\u4f53\u517b\u62a4\u4e13\u9879\u914d\u65b9"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>\u524d\u8a00<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u968f\u7740\u73b0\u4ee3\u793e\u4ea4\u573a\u666f\u5e38\u6001\u5316\uff0c\u6210\u4eba\u9636\u6bb5\u6027\u9152\u7cbe\u6444\u5165\u3001\u4f5c\u606f\u4e0d\u89c4\u5f8b\u7b49\u751f\u6d3b\u65b9\u5f0f\uff0c\u6301\u7eed\u7ed9\u809d\u810f\u7ec6\u80de\u4ee3\u8c22\u3001\u7ebf\u7c92\u4f53\u7a33\u6001\u5e26\u6765\u6301\u7eed\u6027\u6c27\u5316\u538b\u529b\u4e0e\u4ee3\u8c22\u8d1f\u8377\u3002\u809d\u810f\u4f5c\u4e3a\u4eba\u4f53\u6838\u5fc3\u4ee3\u8c22\u5668\u5b98\uff0c\u627f\u62c590%\u4ee5\u4e0a\u7684\u9152\u7cbe\u4ee3\u8c22\u5de5\u4f5c\uff0c\u5176\u7ec6\u80de\u5185\u8f85\u9176\u5e73\u8861\u3001\u7ebf\u7c92\u4f53\u529f\u80fd\u72b6\u6001\uff0c\u76f4\u63a5\u51b3\u5b9a\u809d\u810f\u4ee3\u8c22\u5065\u5eb7\u6c34\u5e73\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u4ea7\u54c1\u8bbe\u8ba1\u57fa\u4e8e\u4eba\u4f53\u9152\u7cbe\u4ee3\u8c22\u5e95\u5c42\u751f\u7269\u673a\u7406\uff0c\u4ee5<strong>NAD\u207a\u8f85\u9176\u8865\u7ed9+PQQ\u7ebf\u7c92\u4f53\u4fee\u62a4<\/strong>\u4e3a\u6838\u5fc3\u590d\u914d\u903b\u8f91\uff0c\u4e0d\u5e72\u9884\u4eba\u4f53\u5148\u5929\u9176\u6d3b\u6027\u3001\u4e0d\u66ff\u4ee3\u4eba\u4f53\u4ee3\u8c22\u529f\u80fd\uff0c\u901a\u8fc7\u7ec6\u80de\u7ea7\u81b3\u98df\u8425\u517b\u8865\u5145\uff0c\u8f85\u52a9\u7ef4\u6301\u809d\u7ec6\u80de\u6c27\u5316\u8fd8\u539f\u5e73\u8861\u3001\u4f18\u5316\u8f85\u9176\u5faa\u73af\u4f53\u7cfb\u3001\u52a9\u529b\u7ebf\u7c92\u4f53\u517b\u62a4\uff0c\u4e3a\u9ad8\u4ee3\u8c22\u538b\u529b\u4eba\u7fa4\u63d0\u4f9b\u79d1\u5b66\u3001\u6e29\u548c\u7684\u81b3\u98df\u8425\u517b\u652f\u6301\u65b9\u6848\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"573\" src=\"https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-1024x573.png\" alt=\"\" class=\"wp-image-858\" srcset=\"https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-1024x573.png 1024w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-300x168.png 300w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-768x429.png 768w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/07\/\u56fe\u72471.png 1268w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u6587\u7cfb\u7edf\u9610\u8ff0\u4ea7\u54c1\u6838\u5fc3\u673a\u7406\u3001\u6210\u5206\u534f\u540c\u903b\u8f91\u3001\u9002\u7528\u573a\u666f\u4e0e\u5408\u89c4\u8bf4\u660e\uff0c\u4e3a\u54c1\u724c\u62db\u5546\u3001\u5e02\u573a\u63a8\u5e7f\u3001\u7ec8\u7aef\u79d1\u666e\u3001\u6e20\u9053\u57f9\u8bad\u63d0\u4f9b\u6807\u51c6\u5316\u4e13\u4e1a\u4f9d\u636e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e00\u3001\u884c\u4e1a\u80cc\u666f\u4e0e\u7528\u6237\u6838\u5fc3\u75db\u70b9<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1.1 \u9152\u7cbe\u4ee3\u8c22\u7684\u666e\u904d\u751f\u7406\u538b\u529b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eba\u4f53\u6444\u5165\u4e59\u9187\u540e\uff0c\u4ec510%\u53ef\u901a\u8fc7\u547c\u5438\u3001\u6c57\u6db2\u3001\u5c3f\u6db2\u76f4\u63a5\u6392\u51fa\uff0c\u5269\u4f5990%\u5747\u9700\u5728\u809d\u7ec6\u80de\u5185\u5b8c\u6210\u4e24\u6b65\u9176\u4fc3\u4ee3\u8c22\u53cd\u5e94\uff0c\u6700\u7ec8\u5206\u89e3\u4e3a\u4e8c\u6c27\u5316\u78b3\u548c\u6c34\u6392\u51fa\u4f53\u5916\u3002\u957f\u671f\u6216\u9636\u6bb5\u6027\u996e\u9152\uff0c\u4f1a\u6301\u7eed\u6253\u7834\u809d\u7ec6\u80de\u7a33\u6001\uff0c\u5f15\u53d1\u591a\u91cd\u4ee3\u8c22\u95ee\u9898\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1.2 \u4e3b\u6d41\u4eba\u7fa4\u6838\u5fc3\u4ee3\u8c22\u75db\u70b9<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8f85\u9176\u6d88\u8017\u5931\u8861<\/strong>\uff1a\u9152\u7cbe\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u4f1a\u6301\u7eed\u6d88\u8017\u6838\u5fc3\u8f85\u9176NAD\u207a\uff0c\u957f\u671f\u3001\u9636\u6bb5\u6027\u6444\u5165\u9152\u7cbe\u6613\u9020\u6210\u809d\u7ec6\u80deNAD\u207a\u50a8\u5907\u4e0b\u964d\u3001NADH\u5806\u79ef\uff0c\u5f15\u53d1\u7ec6\u80de\u6c27\u5316\u8fd8\u539f\u5931\u8861\uff0c\u63d0\u5347\u809d\u810f\u4ee3\u8c22\u538b\u529b\uff1b<\/li>\n\n\n\n<li><strong>\u4e59\u919b\u884d\u751f\u6c27\u5316\u538b\u529b<\/strong>\uff1a\u9152\u7cbe\u4ee3\u8c22\u4e2d\u95f4\u4ea7\u7269\u4e59\u919b\u5b58\u5728\u7ec6\u80de\u523a\u6fc0\u6027\uff0c\u6613\u8bf1\u5bfc\u751f\u6210\u8fc7\u91cf\u6d3b\u6027\u6c27\u81ea\u7531\u57fa\uff08ROS\uff09\uff0c\u53ef\u80fd\u5f71\u54cd\u7ebf\u7c92\u4f53\u819c\u3001\u7ebf\u7c92\u4f53DNA\u72b6\u6001\uff0c\u5bf9\u809d\u7ec6\u80de\u7a33\u6001\u9020\u6210\u6f5c\u5728\u5f71\u54cd\uff1b<\/li>\n\n\n\n<li><strong>\u7ebf\u7c92\u4f53\u4ee3\u8c22\u6d3b\u529b\u4e0b\u964d<\/strong>\uff1a\u957f\u671f\u6c27\u5316\u538b\u529b\u7d2f\u79ef\uff0c\u6613\u5f71\u54cd\u7ebf\u7c92\u4f53\u6b63\u5e38\u66f4\u65b0\u4e0e\u547c\u5438\u529f\u80fd\uff0c\u964d\u4f4eNAD\u207a\u5faa\u73af\u518d\u751f\u6548\u7387\uff0c\u9010\u6b65\u5f62\u6210\u201c\u4ee3\u8c22\u538b\u529b\u504f\u9ad8\u3001\u7ec6\u80de\u4fee\u62a4\u504f\u5f31\u201d\u7684\u4e0d\u826f\u72b6\u6001\uff1b<\/li>\n\n\n\n<li><strong>\u4eba\u7fa4\u5148\u5929\u4ee3\u8c22\u5dee\u5f02<\/strong>\uff1a\u4e1c\u4e9a\u4eba\u7fa4\u666e\u904d\u5b58\u5728ALDH2\u57fa\u56e0\u591a\u6001\u6027\u7279\u5f81\uff0c\u4e59\u919b\u4ee3\u8c22\u6548\u7387\u76f8\u5bf9\u504f\u4f4e\uff0c\u66f4\u6613\u51fa\u73b0\u4ee3\u8c22\u4e0d\u9002\u3001\u6c27\u5316\u538b\u529b\u7d2f\u79ef\u7b49\u60c5\u51b5\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1.3 \u73b0\u6709\u8425\u517b\u8865\u5145\u65b9\u6848\u5c40\u9650\u6027<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ee\u524d\u5e02\u573a\u5355\u4e00\u8425\u517b\u8865\u5145\u65b9\u6848\u5b58\u5728\u660e\u663e\u9002\u914d\u5c40\u9650\uff1a\u5355\u4e00NAD\u207a\u524d\u4f53\u8865\u5145\u4ec5\u53ef\u5b9e\u73b0\u5916\u6e90\u8f85\u9176\u8865\u7ed9\uff0c\u96be\u4ee5\u6539\u5584\u9152\u7cbe\u4ee3\u8c22\u5f15\u53d1\u7684NADH\u5806\u79ef\u3001\u7ebf\u7c92\u4f53\u72b6\u6001\u5931\u8861\u3001\u8f85\u9176\u5faa\u73af\u4e0d\u7545\u7b49\u95ee\u9898\uff1b\u5355\u4e00PQQ\u8865\u5145\u4ec5\u53ef\u517b\u62a4\u7ebf\u7c92\u4f53\u72b6\u6001\uff0c\u7f3a\u5c11\u9152\u7cbe\u4ee3\u8c22\u6240\u9700\u7684\u6838\u5fc3\u8f85\u9176\u5e95\u7269\uff0c\u96be\u4ee5\u9002\u914d\u809d\u810f\u9ad8\u4ee3\u8c22\u538b\u529b\u573a\u666f\uff0c\u4e8c\u8005\u5355\u72ec\u4f7f\u7528\u5747\u65e0\u6cd5\u5f62\u6210\u5b8c\u6574\u7684\u81b3\u98df\u8425\u517b\u652f\u6301\u4f53\u7cfb\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e8c\u3001\u6838\u5fc3\u5e95\u5c42\u673a\u7406\uff1a\u4eba\u4f53\u9152\u7cbe\u4ee3\u8c22\u5b8c\u6574\u901a\u8def<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eba\u4f53\u809d\u810f\u9152\u7cbe\u4ee3\u8c22\u4e3a\u4e24\u6b65\u4e13\u5c5e\u9176\u4fc3\u53cd\u5e94\uff0c<strong>\u4e59\u9187\u8131\u6c22\u9176\uff08ADH\uff09\u3001\u4e59\u919b\u8131\u6c22\u9176\uff08ALDH\uff09\u4e24\u5927\u6838\u5fc3\u9176\uff0c\u5168\u7a0b\u4e13\u4e00\u4f9d\u8d56NAD\u207a\u4f5c\u4e3a\u552f\u4e00\u8f85\u9176<\/strong>\uff0c\u65e0\u4efb\u4f55\u66ff\u4ee3\u7269\u8d28\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/07\/\u56fe\u72472.png\" alt=\"\" class=\"wp-image-859\" srcset=\"https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/07\/\u56fe\u72472.png 1024w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/07\/\u56fe\u72472-300x300.png 300w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/07\/\u56fe\u72472-150x150.png 150w, https:\/\/shandong.nugene.com.cn\/wp-content\/uploads\/2026\/07\/\u56fe\u72472-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2.1 \u7b2c\u4e00\u6b65\uff1a\u4e59\u9187\u8f6c\u5316\u4e3a\u4e59\u919b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4e59\u9187\u8131\u6c22\u9176\uff08ADH\uff09\u4f5c\u7528\u4e0b\uff0c\u4e59\u9187\u7ed3\u5408\u8f85\u9176NAD\u207a\u53d1\u751f\u6c27\u5316\u53cd\u5e94\uff0c\u751f\u6210\u6bd2\u6027\u4e2d\u95f4\u4ea7\u7269\u4e59\u919b\uff0c\u540c\u65f6NAD\u207a\u88ab\u8fd8\u539f\u4e3aNADH\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53cd\u5e94\u516c\u5f0f\uff1aC\u2082H\u2085OH + NAD\u207a \u2192 CH\u2083CHO + NADH + H\u207a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2.2 \u7b2c\u4e8c\u6b65\uff1a\u4e59\u919b\u8f6c\u5316\u4e3a\u4e59\u9178<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4e59\u919b\u8131\u6c22\u9176\uff08ALDH\uff09\u4f5c\u7528\u4e0b\uff0c\u6709\u6bd2\u4e59\u919b\u518d\u6b21\u7ed3\u5408NAD\u207a\uff0c\u6c27\u5316\u5206\u89e3\u4e3a\u65e0\u6bd2\u4e59\u9178\uff0c\u540c\u65f6\u518d\u6b21\u751f\u6210NADH\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53cd\u5e94\u516c\u5f0f\uff1aCH\u2083CHO + H\u2082O + NAD\u207a \u2192 CH\u2083COOH + NADH + H\u207a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2.3 \u6700\u7ec8\u4ee3\u8c22\u7ec8\u70b9<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e59\u9178\u8fdb\u5165\u4eba\u4f53\u4e09\u7fa7\u9178\u5faa\u73af\uff0c\u5f7b\u5e95\u5206\u89e3\u4e3a\u4e8c\u6c27\u5316\u78b3\u4e0e\u6c34\uff0c\u5b8c\u6210\u9152\u7cbe\u5b8c\u6574\u4ee3\u8c22\u8fc7\u7a0b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2.4 \u6838\u5fc3\u79d1\u5b66\u7ed3\u8bba<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7efc\u5408\u79d1\u7814\u7ed3\u8bba\u8868\u660e\uff1a\u9152\u7cbe\u4ee3\u8c22\u7684\u4e3b\u8981\u9650\u5236\u6027\u56e0\u7d20\uff0c\u5728\u4e8e<strong>\u809d\u7ec6\u80de\u5185NAD\u207a\u7684\u50a8\u5907\u6c34\u5e73\u4e0e\u5faa\u73af\u518d\u751f\u6548\u7387<\/strong>\uff1b\u540c\u65f6\uff0c\u4ee3\u8c22\u8fc7\u7a0b\u4ea7\u751f\u7684\u6c27\u5316\u538b\u529b\u6613\u5f71\u54cd\u7ebf\u7c92\u4f53\u6b63\u5e38\u529f\u80fd\uff0c\u95f4\u63a5\u5236\u7ea6NAD\u207a\u518d\u751f\uff0c\u52a0\u91cd\u809d\u810f\u4ee3\u8c22\u8d1f\u62c5\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e09\u3001\u6838\u5fc3\u6210\u5206\u529f\u6548\u673a\u7406<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u4ea7\u54c1\u7504\u9009NAD\u207a\u524d\u4f53\u4e0ePQQ\uff08\u5421\u54af\u5e76\u55b9\u5549\u918c\uff0c\u65b0\u98df\u54c1\u539f\u6599\uff09\u79d1\u5b66\u914d\u6bd4\u590d\u914d\uff0c\u53cc\u6210\u5206\u5404\u53f8\u5176\u804c\u3001\u76f8\u4e92\u534f\u540c\uff0c\u4ece\u300c\u5e95\u7269\u8865\u7ed9\u3001\u5faa\u73af\u518d\u751f\u3001\u6297\u6c27\u5316\u517b\u62a4\u3001\u7a33\u6001\u8c03\u63a7\u300d\u56db\u4e2a\u7ef4\u5ea6\uff0c\u642d\u5efa\u809d\u7ec6\u80de\u4ee3\u8c22\u8425\u517b\u652f\u6301\u4f53\u7cfb\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3.1 NAD\u207a\uff1a\u9152\u7cbe\u4ee3\u8c22\u7684\u6838\u5fc3\u521a\u9700\u8f85\u9176<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">NAD\u207a\uff08\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff09\u662f\u4eba\u4f53\u4e0a\u5343\u79cd\u4ee3\u8c22\u9176\u7684\u5fc5\u9700\u8f85\u9176\uff0c\u4e5f\u662f\u809d\u810f\u9152\u7cbe\u4ee3\u8c22\u901a\u8def\u7684\u6838\u5fc3\u57fa\u7840\u5e95\u7269\uff0c\u662f\u4eba\u4f53\u4ee3\u8c22\u8fd0\u8f6c\u7684\u91cd\u8981\u8425\u517b\u7269\u8d28\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5e95\u7269\u8865\u7ed9\u652f\u6301<\/strong>\uff1a\u4e3aADH\u3001ALDH\u9176\u4fc3\u53cd\u5e94\u8865\u5145\u8f85\u9176\u539f\u6599\uff0c\u52a9\u529b\u809d\u810f\u9152\u7cbe\u4ee3\u8c22\u901a\u8def\u5e73\u7a33\u8fd0\u8f6c\uff0c\u7f13\u89e3\u9636\u6bb5\u6027\u996e\u9152\u5e26\u6765\u7684NAD\u207a\u6d88\u8017\u95ee\u9898\uff1b<\/li>\n\n\n\n<li><strong>\u8f85\u52a9\u8c03\u63a7\u7ec6\u80de\u72b6\u6001<\/strong>\uff1a\u52a9\u529b\u6fc0\u6d3bSirtuins\u957f\u5bff\u86cb\u767d\u5bb6\u65cf\uff0c\u8f85\u52a9\u809d\u7ec6\u80de\u72b6\u6001\u8c03\u7406\u3001\u4ee3\u8c22\u8282\u5f8b\u4f18\u5316\uff0c\u6539\u5584\u809d\u7ec6\u80de\u4ee3\u8c22\u73af\u5883\uff1b<\/li>\n\n\n\n<li><strong>\u5e73\u8861\u6c27\u5316\u8fd8\u539f\u72b6\u6001<\/strong>\uff1a\u5e2e\u52a9\u7ef4\u6301\u7ec6\u80de\u5185NAD\u207a\/NADH\u5408\u7406\u6bd4\u503c\uff0c\u8212\u7f13\u9152\u7cbe\u4ee3\u8c22\u5f15\u53d1\u7684\u7ec6\u80de\u6c27\u5316\u8fd8\u539f\u6ce2\u52a8\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3.2 PQQ\uff1a\u7ebf\u7c92\u4f53\u4e13\u5c5e\u4fee\u62a4\u4e0e\u518d\u751f\u56e0\u5b50<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5408\u89c4\u79d1\u5b66\u8bf4\u660e\uff1a<strong>PQQ\u5e76\u975e\u4eba\u4f53\u9152\u7cbe\u4ee3\u8c22\u9176\u7684\u8f85\u9176<\/strong>\uff08PQQ\u4f9d\u8d56\u578b\u8131\u6c22\u9176\u4ec5\u5b58\u5728\u4e8e\u5fae\u751f\u7269\uff0c\u4eba\u4f53\u65e0\u5bf9\u5e94\u4f5c\u7528\u4f53\u7cfb\uff09\u3002PQQ\u7684\u6838\u5fc3\u4ef7\u503c\u662f\u9488\u5bf9\u6027\u517b\u62a4\u809d\u7ec6\u80de\u7ebf\u7c92\u4f53\uff0c\u6539\u5584\u7ebf\u7c92\u4f53\u72b6\u6001\uff0c\u758f\u901aNAD\u207a\u5faa\u73af\u4e0d\u7545\u7684\u95ee\u9898\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u52a9\u529b\u7ebf\u7c92\u4f53\u65b0\u751f<\/strong>\uff1a\u6fc0\u6d3bPGC-1\u03b1\u6838\u5fc3\u901a\u8def\uff0c\u52a9\u529b\u5065\u5eb7\u7ebf\u7c92\u4f53\u751f\u6210\uff0c\u63d0\u5347\u809d\u7ec6\u80de\u7ebf\u7c92\u4f53\u6574\u4f53\u6d3b\u6027\u4e0e\u547c\u5438\u4ee3\u8c22\u80fd\u529b\uff0c\u4f18\u5316\u809d\u810f\u4ee3\u8c22\u57fa\u7840\u73af\u5883\uff1b<\/li>\n\n\n\n<li><strong>\u52a9\u529b\u8f85\u9176\u5faa\u73af\u66f4\u65b0<\/strong>\uff1a\u4f18\u5316\u7ebf\u7c92\u4f53\u547c\u5438\u94fe\u8fd0\u8f6c\u72b6\u6001\uff0c\u8f85\u52a9\u9152\u7cbe\u4ee3\u8c22\u4ea7\u751f\u7684NADH\u8f6c\u5316\u4e3a\u6d3b\u6027NAD\u207a\uff0c\u6539\u5584\u8f85\u9176\u5806\u79ef\u3001\u5faa\u73af\u6ede\u540e\u7684\u4ee3\u8c22\u95ee\u9898\uff1b<\/li>\n\n\n\n<li><strong>\u8212\u7f13\u6c27\u5316\u5e94\u6fc0\u72b6\u6001<\/strong>\uff1a\u4f9d\u6258\u53ef\u9006\u6c27\u5316\u8fd8\u539f\u7279\u6027\uff0c\u7f13\u51b2\u9152\u7cbe\u4ee3\u8c22\u4ea7\u751f\u7684ROS\u6d3b\u6027\u6c27\u5f71\u54cd\uff0c\u51cf\u8f7b\u4e59\u919b\u5e26\u6765\u7684\u7ec6\u80de\u6c27\u5316\u538b\u529b\uff0c\u5475\u62a4\u7ebf\u7c92\u4f53\u4e0e\u809d\u7ec6\u80de\u7a33\u6001\uff1b<\/li>\n\n\n\n<li><strong>\u534f\u540c\u4f18\u5316\u4ee3\u8c22\u73af\u5883<\/strong>\uff1a\u4e0eNAD\u207a\u534f\u540c\u4f5c\u7528\u4e8eAMPK-SIRT1\u4fe1\u53f7\u8f74\uff0c\u7a33\u5b9a\u809d\u7ec6\u80de\u4ee3\u8c22\u72b6\u6001\uff0c\u51cf\u7f13\u957f\u671f\u4ee3\u8c22\u538b\u529b\u5e26\u6765\u7684\u7ec6\u80de\u72b6\u6001\u7d2f\u79ef\u504f\u5dee\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u56db\u3001NAD\u207a+PQQ \u590d\u914d\u534f\u540c\u6838\u5fc3\u4f18\u52bf<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53cc\u6210\u5206\u590d\u914d\u6a21\u5f0f\u5f25\u8865\u4e86\u5355\u4e00\u8425\u517b\u8865\u5145\u7684\u9002\u914d\u77ed\u677f\uff0c\u5f62\u6210<strong>\u201c\u5916\u6e90\u8865\u7ed9+\u5185\u6e90\u66f4\u65b0+\u957f\u6548\u517b\u62a4\u201d\u7684\u95ed\u73af\u8425\u517b\u652f\u6301\u4f53\u7cfb<\/strong>\uff0c\u5b9e\u73b0\u53cc\u6210\u5206\u534f\u540c\u589e\u76ca\u7684\u81b3\u98df\u8425\u517b\u8865\u5145\u6548\u679c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4.1 \u5355\u4e00\u6210\u5206\u77ed\u677f<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5355\u72ec\u8865\u5145NAD\u207a<\/strong>\uff1a\u4ec5\u53ef\u5916\u6e90\u63d0\u5347\u8f85\u9176\u57fa\u7840\u6c34\u5e73\uff0c\u96be\u4ee5\u6539\u5584NADH\u5806\u79ef\u3001\u7ebf\u7c92\u4f53\u72b6\u6001\u5931\u8861\u95ee\u9898\uff0c\u8f85\u9176\u5faa\u73af\u6548\u7387\u6709\u9650\uff0c\u65e0\u6cd5\u957f\u6548\u8212\u7f13\u809d\u810f\u4ee3\u8c22\u538b\u529b\uff1b<\/li>\n\n\n\n<li><strong>\u5355\u72ec\u8865\u5145PQQ<\/strong>\uff1a\u4ec5\u53ef\u517b\u62a4\u7ebf\u7c92\u4f53\u3001\u4f18\u5316\u4ee3\u8c22\u73af\u5883\uff0c\u7f3a\u5c11\u9152\u7cbe\u4ee3\u8c22\u6240\u9700\u7684NAD\u207a\u8f85\u9176\u5e95\u7269\uff0c\u96be\u4ee5\u9002\u914d\u809d\u810f\u9ad8\u8d1f\u8377\u4ee3\u8c22\u573a\u666f\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4.2 \u590d\u914d\u534f\u540c\u56db\u91cd\u95ed\u73af\u4f53\u7cfb<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5e95\u7269\u4fdd\u969c\u5c42<\/strong>\uff1aNAD\u207a\u8865\u5145\u9152\u7cbe\u4ee3\u8c22\u6240\u9700\u6838\u5fc3\u8f85\u9176\u539f\u6599\uff0c\u52a9\u529b\u809d\u810f\u57fa\u7840\u4ee3\u8c22\u901a\u8def\u5e73\u7a33\u8fd0\u8f6c\uff1b<\/li>\n\n\n\n<li><strong>\u5faa\u73af\u66f4\u65b0\u5c42<\/strong>\uff1aPQQ\u4f18\u5316\u7ebf\u7c92\u4f53\u529f\u80fd\uff0c\u8f85\u52a9NADH\u9006\u5411\u8f6c\u5316\u4e3a\u6d3b\u6027NAD\u207a\uff0c\u52a9\u529b\u8f85\u9176\u5faa\u73af\u5229\u7528\uff0c\u8212\u7f13\u8f85\u9176\u6d88\u8017\u5e26\u6765\u7684\u4ee3\u8c22\u538b\u529b\uff1b<\/li>\n\n\n\n<li><strong>\u6c27\u5316\u9632\u62a4\u5c42<\/strong>\uff1aPQQ\u8212\u7f13\u4ee3\u8c22\u4ea7\u751f\u7684\u6c27\u5316\u538b\u529b\uff0c\u517b\u62a4\u7ebf\u7c92\u4f53\u72b6\u6001\uff0c\u7f13\u51b2\u4e59\u919b\u7684\u7ec6\u80de\u523a\u6fc0\u5f71\u54cd\uff0c\u7ef4\u62a4\u809d\u810f\u4ee3\u8c22\u7a33\u6001\uff1b<\/li>\n\n\n\n<li><strong>\u7a33\u6001\u8c03\u7406\u5c42<\/strong>\uff1a\u53cc\u6210\u5206\u534f\u540c\u6fc0\u6d3b\u6838\u5fc3\u4ee3\u8c22\u901a\u8def\uff0c\u957f\u671f\u8f85\u52a9\u7ef4\u6301\u809d\u7ec6\u80de\u6c27\u5316\u8fd8\u539f\u5e73\u8861\uff0c\u51cf\u7f13\u4ee3\u8c22\u538b\u529b\u5e26\u6765\u7684\u72b6\u6001\u7d2f\u79ef\u504f\u5dee\u3002<\/li>\n<\/ul>\n\n\n\n<p 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